DCrk
DCrk (Drosophila ortholog of Crk) is the Drosophila melanogaster ortholog of the mammalian proteins Crk and CrkL.[1]
| Crk oncogene | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Crk | ||||||
| UniProt | Q95RW2 | ||||||
| |||||||
Structure and function
DCrk includes one SH2 domain followed by two SH3 domains and interacts with the MyoBlast City (MCB) protein. The DCrk protein is expressed during embryogenesis, declines during the larval stages, and reappears during pupation which suggests that DCrk plays an important role in development.[1]
References
- Galletta BJ, Niu XP, Erickson MR, Abmayr SM (March 1999). "Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC". Gene. 228 (1–2): 243–52. doi:10.1016/S0378-1119(99)00010-4. PMID 10072777.
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