DENND1A

DENN domain-containing protein 1A is a protein that in humans is encoded by the DENND1A gene.[5][6]

DENND1A
Identifiers
Aliases	DENND1A, FAM31A, KIAA1608, DENN domain containing 1A
External IDs	OMIM: 613633 MGI: 2442794 HomoloGene: 17141 GeneCards: DENND1A
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 123,379,654 bp[1] End 123,930,152 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 37,798,991 bp[2] End 38,287,390 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • SH3 domain binding • lipid binding • phosphatidylinositol phosphate binding • Rab GTPase binding • phosphatidylinositol-3-phosphate binding • Rab guanyl-nucleotide exchange factor activity Cellular component • membrane • cell membrane • synapse • cell junction • neuronal cell body • dendrite • clathrin-coated vesicle membrane • presynaptic membrane • cytoplasmic vesicle • clathrin-coated vesicle • nucleoplasm • cytosol • intracellular membrane-bounded organelle Biological process • endocytosis • regulation of Rab protein signal transduction • synaptic vesicle endocytosis • protein transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • endocytic recycling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57706	227801
Ensembl	ENSG00000119522	ENSMUSG00000035392
UniProt	Q8TEH3	Q8K382
RefSeq (mRNA)	NM_020946 NM_024820 NM_001352964 NM_001352965 NM_001352966 NM_001352967 NM_001352968	NM_146122 NM_001362973 NM_001362977 NM_001362978
RefSeq (protein)	NP_065997 NP_079096 NP_001339893 NP_001339894 NP_001339895 NP_001339896 NP_001339897	NP_666234 NP_001349902 NP_001349906 NP_001349907
Location (UCSC)	Chr 9: 123.38 – 123.93 Mb	Chr 2: 37.8 – 38.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000119522 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035392 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
6. "Entrez Gene: DENND1A DENN/MADD domain containing 1A".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.