DGKB

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[4][5]

DGKB
Identifiers
Aliases	DGKB, DAGK2, DGK, DGK-BETA, diacylglycerol kinase beta
External IDs	OMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB
Gene location (Mouse) Chr. Chromosome 12 (mouse)[1] Band 12|12 A3 Start 37,817,726 bp[1] End 38,634,239 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • calcium ion binding • ATP binding • metal ion binding • kinase activity • diacylglycerol kinase activity • NAD+ kinase activity Cellular component • cytoplasm • cell nucleus • cytosol • cell membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse Biological process • platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • GO:0007243 intracellular signal transduction • phosphorylation • glycerolipid metabolic process • lipid phosphorylation • metabolism • signal transduction • response to bacterium • modulation of chemical synaptic transmission • regulation of postsynapse organization • diacylglycerol metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1607	217480
Ensembl	ENSG00000136267	ENSMUSG00000036095
UniProt	Q9Y6T7	Q6NS52
RefSeq (mRNA)	NM_004080 NM_145695	NM_178681 NM_001361686 NM_001361688
RefSeq (protein)	NP_663733 NP_001337634 NP_001337635 NP_001337636 NP_001337637 NP_001337638 NP_001337640 NP_001337641 NP_001337643 NP_001337644 NP_001337645 NP_001337646 NP_001337647 NP_001337648 NP_001337649 NP_001337650 NP_001337651 NP_001337652 NP_001337653	NP_848796 NP_001348615 NP_001348617
Location (UCSC)	n/a	Chr 12: 37.82 – 38.63 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000036095 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proceedings of the National Academy of Sciences of the United States of America. 90 (16): 7598–602. Bibcode:1993PNAS...90.7598G. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.
5. "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".

Further reading

• Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, Goto K, Terstappen GC (February 2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". The Journal of Biological Chemistry. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.