DGKD

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.[5][6][7]

DGKD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1R79, 3BQ7
Identifiers
Aliases	DGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta, DGK-delta
External IDs	OMIM: 601826 MGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,354,507 bp[1] End 233,472,104 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,853,287 bp[2] End 87,945,180 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • diacylglycerol kinase activity • metal ion binding • kinase activity • GO:0001948 protein binding • diacylglycerol binding • ATP binding • NAD+ kinase activity • identical protein binding • protein homodimerization activity • protein heterodimerization activity Cellular component • cytoplasm • membrane • cell membrane • cell nucleus • cytosol • cytoplasmic vesicle Biological process • GO:0007243 intracellular signal transduction • endocytosis • epidermal growth factor receptor signaling pathway • phosphorylation • response to organic substance • platelet activation • multicellular organism development • cell growth • protein kinase C-activating G-protein coupled receptor signaling pathway • diacylglycerol metabolic process • protein transport • second-messenger-mediated signaling • protein homooligomerization • lipid phosphorylation • metabolism • signal transduction • glycerolipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8527	227333
Ensembl	ENSG00000077044 ENSG00000280873	ENSMUSG00000070738
UniProt	Q16760	n/a
RefSeq (mRNA)	NM_003648 NM_152879 NM_001377259	NM_177646
RefSeq (protein)	NP_003639 NP_690618 NP_001364188	n/a
Location (UCSC)	Chr 2: 233.35 – 233.47 Mb	Chr 1: 87.85 – 87.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.[7]

References

1. ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070738 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
6. Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723.
7. "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Further reading

• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Bregoli L, Baldassare JJ, Raben DM (2001). "Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin". J. Biol. Chem. 276 (26): 23288–95. doi:10.1074/jbc.M101501200. PMID 11309392.
• Nagaya H, Wada I, Jia YJ, Kanoh H (2002). "Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains". Mol. Biol. Cell. 13 (1): 302–16. doi:10.1091/mbc.01-05-0255. PMC 65090. PMID 11809841.
• Imai S, Sakane F, Kanoh H (2002). "Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation". J. Biol. Chem. 277 (38): 35323–32. doi:10.1074/jbc.M202035200. PMID 12084710.
• Sakane F, Imai S, Yamada K, et al. (2003). "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions". J. Biol. Chem. 277 (45): 43519–26. doi:10.1074/jbc.M206895200. PMID 12200442.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imai S, Kai M, Yamada K, et al. (2005). "The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain". Biochem. J. 382 (Pt 3): 957–66. doi:10.1042/BJ20040681. PMC 1133971. PMID 15228384.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Leach NT, Sun Y, Michaud S, et al. (2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice". Am. J. Hum. Genet. 80 (4): 792–9. doi:10.1086/513019. PMC 1852716. PMID 17357084.