DIXDC1

Dixin is a protein that in humans is encoded by the DIXDC1 gene.[5][6] When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.[7]

DIXDC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PZ7
Identifiers
Aliases	DIXDC1, CCD1, DIX domain containing 1
External IDs	OMIM: 610493 MGI: 2679721 HomoloGene: 82369 GeneCards: DIXDC1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,927,144 bp[1] End 112,022,653 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 50,662,752 bp[2] End 50,739,517 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • gamma-tubulin binding • GO:0001948 protein binding • protein domain specific binding Cellular component • cytosol • cell junction • focal adhesion • cytoplasm • cytoskeleton Biological process • positive regulation of canonical Wnt signaling pathway • multicellular organism development • positive regulation of Wnt signaling pathway • regulation of microtubule cytoskeleton organization • forebrain ventricular zone progenitor cell division • cerebral cortex radially oriented cell migration • cerebral cortex cell migration • regulation of actin cytoskeleton organization • negative regulation of neuron differentiation • Wnt signaling pathway • cell proliferation in forebrain • canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85458	330938
Ensembl	ENSG00000150764	ENSMUSG00000032064
UniProt	Q155Q3	Q80Y83
RefSeq (mRNA)	NM_001037954 NM_001278542 NM_033425	NM_178118 NM_001311069 NM_001374656
RefSeq (protein)	NP_001033043 NP_001265471 NP_219493	NP_001297998 NP_835219 NP_001361585
Location (UCSC)	Chr 11: 111.93 – 112.02 Mb	Chr 9: 50.66 – 50.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000150764 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032064 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (July 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". International Journal of Oncology. 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID 12792787.
6. "Entrez Gene: DIXDC1 DIX domain containing 1".
7. http://medicalxpress.com/news/2014-07-gene-deadly-cancer.html#nRlv

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (December 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara A (August 2003). "Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets". Oncogene. 22 (35): 5525–36. doi:10.1038/sj.onc.1206853. PMID 12934113.
• Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC (September 2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms". The Journal of Biological Chemistry. 279 (38): 39366–73. doi:10.1074/jbc.M404598200. PMID 15262978.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang X, Zheng L, Zeng Z, Zhou G, Chien J, Qian C, Vasmatzis G, Shridhar V, Chen L, Liu W (August 2006). "DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein". Biochemical and Biophysical Research Communications. 347 (1): 22–30. doi:10.1016/j.bbrc.2006.06.050. PMID 16814745.