dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (EC 2.6.1.33) is an enzyme that catalyzes the chemical reaction
- dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate
| dTDP-4-amino-4,6-dideoxy-D-glucose transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.33 | ||||||||
| CAS number | 9023-19-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are dTDP-4-amino-4,6-dideoxy-D-glucose and 2-oxoglutarate, whereas its two products are dTDP-4-dehydro-6-deoxy-D-glucose and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase. Other names in common use include thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase, thymidine diphospho-4-amino-6-deoxyglucose aminotransferase, thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase, thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase, and TDP-4-keto-6-deoxy-D-glucose transaminase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, pyridoxal phosphate.
References
- Matsuhashi M, Strominger JL (1966). "Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3 Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B". J. Biol. Chem. 241 (20): 4738–44. PMID 5332731.