Daniel Haber

Daniel A. Haber is the director of the Massachusetts General Hospital Cancer Center, a professor of oncology at Harvard Medical School, and an investigator of the Howard Hughes Medical Institute (HHMI).

For the footballer, see Daniel Haber (soccer).
Daniel A. Haber
NationalityFrench
Alma materMassachusetts Institute of Technology, Stanford University
Known forCancer Genetics
Scientific career
FieldsGenetics
InstitutionsHarvard University

Career

Haber earned his B.S. in life sciences and M.S. in toxicology from Massachusetts Institute of Technology, and his M.D. and Ph.D. in biophysics from Stanford University School of Medicine under the mentorship of Robert T. Schimke.[1] He did his postdoctoral training at Massachusetts Institute of Technology with David E. Housman.[2]

As a postdoc, he started to study Wilms' tumor and characterized the tumor suppressor gene WT1 and WTX.[3][4] In 2003, he recognized that certain patients with lung cancer responded well to the drug Iressa where few other patients showed effect. Sequencing the patient's cancers, they identified specific mutation in epidermal growth factor receptor (EGFR) that resulted in sensitivity to certain drugs.[5][6] By linking mutations to drug sensitivity, they were able to propose new mechanisms for targeted therapies by examining the accumulation of certain mutations in cancer cells.[1] His lab is now focused on studying the genetics of cancer particularly in circulating tumor cells with Mehmet Toner.

He is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Medicine, the National Academy of Sciences, the Association of American Physicians, and the American Society for Clinical Investigation. He is an editor of Cell and Cancer Cell.[2]

References
  1. "Daniel A. Haber". HHMI. Retrieved 10 November 2012.
  2. "Daniel Haber, M.D., Ph.D." Retrieved 10 November 2012.
  3. Haber, DA; Buckler, AJ; Glaser, T; Call, KM; Pelletier, J; Sohn, RL; Douglass, EC; Housman, DE (Jun 29, 1990). "An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor". Cell. 61 (7): 1257–69. doi:10.1016/0092-8674(90)90690-g. PMID 2163761. S2CID 11931372.
  4. "MERIT Award Recipient: Daniel A. Haber, M.D., Ph.D." Retrieved 10 November 2012.
  5. Lynch, Thomas J.; Bell, Daphne W.; Sordella, Raffaella; Gurubhagavatula, Sarada; Okimoto, Ross A.; Brannigan, Brian W.; Harris, Patricia L.; Haserlat, Sara M.; Supko, Jeffrey G.; Haluska, Frank G.; Louis, David N.; Christiani, David C.; Settleman, Jeff; Haber, Daniel A. (20 May 2004). "Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib" (PDF). New England Journal of Medicine. 350 (21): 2129–2139. doi:10.1056/NEJMoa040938. PMID 15118073.
  6. Sordella, R; Bell, DW; Haber, DA; Settleman, J (Aug 20, 2004). "Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways". Science. 305 (5687): 1163–7. Bibcode:2004Sci...305.1163S. doi:10.1126/science.1101637. PMID 15284455. S2CID 34389318.


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