Deleted in lung and esophageal cancer 1

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. [5]

DLEC1
Identifiers
Aliases	DLEC1, CFAP81, DLC1, F56, DLC-1, deleted in lung and esophageal cancer 1, cilia and flagella associated protein, DLEC1 cilia and flagella associated protein, FAP81
External IDs	OMIM: 604050 MGI: 2443671 HomoloGene: 84733 GeneCards: DLEC1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,039,205 bp[1] End 38,124,025 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 119,102,478 bp[2] End 119,148,246 bp[2]
Gene ontology Molecular function • molecular function Cellular component • cytoplasm • cytosol Biological process • negative regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9940	320256
Ensembl	ENSG00000008226	ENSMUSG00000038060
UniProt	Q9Y238 Q32W76	Q8BLA1
RefSeq (mRNA)	NM_007335 NM_007336 NM_007337 NM_007338 NM_001321153	NM_177117 NM_001368820 NM_001368821
RefSeq (protein)	NP_001308082 NP_031361 NP_031363	n/a
Location (UCSC)	Chr 3: 38.04 – 38.12 Mb	Chr 9: 119.1 – 119.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000008226 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038060 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

Further reading

• Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, Welch WR, Berkowitz RS, Mok SC (April 2006). "Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer". Neoplasia. 8 (4): 268–78. doi:10.1593/neo.05502. PMC 1600675. PMID 16756719.
• Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW (February 2007). "Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma". Genes Chromosomes Cancer. 46 (2): 171–80. doi:10.1002/gcc.20398. PMID 17099870. S2CID 45238991.
• Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, Chen GG, Harrison D, Lai P, Tao Q, Hooi SC (March 2008). "The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle". J. Hepatol. 48 (3): 433–41. doi:10.1016/j.jhep.2007.11.015. PMID 18191269.
• Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR (July 2008). "DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma". Br. J. Cancer. 99 (2): 375–82. doi:10.1038/sj.bjc.6604452. PMC 2480971. PMID 18594535.
• Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q (February 2009). "DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers". Br. J. Cancer. 100 (4): 663–9. doi:10.1038/sj.bjc.6604888. PMC 2653732. PMID 19156137.
• Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P (April 2009). "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project" (PDF). Cancer Res. 69 (7): 2956–65. doi:10.1158/0008-5472.CAN-08-2604. PMID 19339270.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K (April 2010). "Evidence of a tumour suppressor function for DLEC1 in human breast cancer". Anticancer Res. 30 (4): 1079–82. PMID 20530412.
• Zhang Y, Miao Y, Yi J, Wang R, Chen L (July 2010). "Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer". Clin Lung Cancer. 11 (4): 264–70. doi:10.3816/CLC.2010.n.034. PMID 20630829.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.