Docking protein 6

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]

DOK6
Identifiers
Aliases	DOK6, DOK5L, HsT3226, docking protein 6
External IDs	OMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.2 Start 69,400,888 bp[1] End 69,849,087 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E4 Start 89,292,424 bp[2] End 89,769,528 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytosol Biological process • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	220164	623279
Ensembl	ENSG00000206052	ENSMUSG00000073514
UniProt	Q6PKX4	Q2MHE5
RefSeq (mRNA)	NM_152721	NM_001039173
RefSeq (protein)	NP_689934	NP_001034262
Location (UCSC)	Chr 18: 69.4 – 69.85 Mb	Chr 18: 89.29 – 89.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

References

1. GRCh38: Ensembl release 89: ENSG00000206052 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073514 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

Further reading

• Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
• Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.