E. Dale Abel

Evan Dale Abel (born 1963) is an American endocrinologist who holds the John B. Stokes III Chair in Diabetes Research and the François M. Abboud Chair in Internal Medicine at the Carver College of Medicine. His research looks to understand the molecular mechanisms that underpin cardiac failure in diabetes. He is a Fellow of the American Heart Association and the American College of Physicians.

Evan Dale Abel
Abel lectures at the National Institutes of Health in 2018
Born1963 (age 57–58)
Alma materUniversity of the West Indies
University of Oxford
Scientific career
InstitutionsNorthwestern University
University of Iowa
University of Utah
ThesisInsulin and blood pressure (1990)
WebsiteAbel Lab

Early life and education

Abel is from Jamaica.[1] He was encouraged by his parents to become a doctor, lawyer or engineer.[1] He completed his undergraduate studies at the University of the West Indies, where he specialised in medicine. He was the first person to graduate with a distinction in medicine from the University. He move to the United Kingdom for his graduate studies, completed his doctoral research in physiology at the University of Oxford. He was a medical intern in surgery and paediatrics at the University of the West Indies, before completing his residency in internal medicine at Northwestern University.[2]

Research and career

Abel started a clinical research fellowship in diabetes at Harvard Medical School in 1992.[3] After completing his fellowship, Abel joined the faculty at Harvard Medical School, where he was appointed co-Director of the fellowship programme at Beth Israel Deaconess Medical Center.[3] At Beth Israel, he worked alongside Barbara Kahn, with whom who identified the relationship between adipose tissue glucose transporter (GLUT4) and insulin resistance. He was recruited to the faculty at the University of Utah in 2000, first as Assistant Professor and eventually as Professor of Medicine.[3] At the time, around 16 million Americans suffered from diabetes, with three quarters of them dying from heart disease or stroke.[4] Abel was supported by the National Institutes of Health to develop a mouse model of diabetes. Abel studied how glucose is delivered to cells.[4] He made use of conditional gene targeting to induce genetic defects that resulted in heart muscle cells being incapable of taking up glucose.[4]

In 2013 Abel moved to the University of Iowa as Chair of the Department of Internal Medicine.[2][5][6] His research looks to understand the molecular mechanisms that underpin cardiac failure in diabetes.[2] He has investigated how diabetes impacts the formation of blood clots; with the increased glucose uptake of platelets in diabetic mice promoting overactivation and excess clotting.[7] Abel was amongst the first rounds of physicians to receive the COVID-19 vaccine.[8]

Awards and honors

Selected publications
  • Boudina, Sihem; Abel, E. Dale (2007-06-26). "Diabetic Cardiomyopathy Revisited". Circulation. 115 (25): 3213–3223. doi:10.1161/circulationaha.106.679597. ISSN 0009-7322.
  • Abel, E. Dale; Peroni, Odile; Kim, Jason K.; Kim, Young-Bum; Boss, Olivier; Hadro, Ed; Minnemann, Timo; Shulman, Gerald I.; Kahn, Barbara B. (2001). "Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver". Nature. 409 (6821): 729–733. doi:10.1038/35055575. ISSN 1476-4687.
  • Boudina, Sihem; Abel, Evan Dale (2010). "Diabetic cardiomyopathy, causes and effects". Reviews in Endocrine and Metabolic Disorders. 11 (1): 31–39. doi:10.1007/s11154-010-9131-7. ISSN 1389-9155. PMC 2914514. PMID 20180026.

References
  1. "Member Spotlight: E. Dale Abel". www.im.org. Retrieved 2021-01-03.
  2. "E. Dale Abel | Department of Internal Medicine". medicine.uiowa.edu. Retrieved 2021-01-02.
  3. "ENDOCRINE SOCIETY 2014 LAUREATE AWARDS". Endocrine Reviews. 2015-07-18. doi:10.1210/er.2014-1022.2016.1. ISSN 1945-7189.
  4. "U's Young Scientist Unraveling Mystery Behind Heart Disease". The Daily Utah Chronicle. 2002-01-16. Retrieved 2021-01-03.
  5. "E. Dale Abel, MD, PhD". Making the Rounds. Retrieved 2021-01-03.
  6. "E. Dale Abel, MD, PhD | Endocrine Society". www.endocrine.org. Retrieved 2021-01-03.
  7. "UI researchers study abnormal blood clotting in diabetes | Carver College of Medicine". medicine.uiowa.edu. Retrieved 2021-01-03.
  8. "'The vaccine is safe': Endocrinologist E. Dale Abel shares his COVID-19 vaccine experience". www.healio.com. Retrieved 2021-01-03.
  9. "Evan Dale Abel, MBBS, DPhil - Faculty Details - U of U School of Medicine - | University of Utah". medicine.utah.edu. Retrieved 2021-01-02.
  10. "Question and Answer with E. Dale Abel". Endocrine News. 2016-03-23. Retrieved 2021-01-02.
  11. "Biography | E. Dale Abel Laboratory". abel.lab.uiowa.edu. Retrieved 2021-01-02.
  12. "Van Meter Award". American Thyroid Association. Retrieved 2021-01-02.
  13. "E. Dale Abel, MD, PhD | Endocrine Society". www.endocrine.org. Retrieved 2021-01-02.
  14. "Evan Dale Abel, MBBS, DPhil - Faculty Details - U of U School of Medicine - | University of Utah". medicine.utah.edu. Retrieved 2021-01-02.
  15. "Five Black Scholars Elected to the National Academy of Medicine". The Journal of Blacks in Higher Education. 2015-10-28. Retrieved 2021-01-03.
  16. "NIH VideoCast - Sugar and the beating heart: the conundrum of heart failure in diabetes". videocast.nih.gov. Retrieved 2021-01-02.
  17. "NIH Clinical Center: 2018 Astute Clinician Lecture". clinicalcenter.nih.gov. Retrieved 2021-01-02.
  18. aldonovan97 (2018-10-03). "Dr. Abel will receive a "History Makers Award" from the African American Museum of Iowa". Diabetes Center News Hub. Retrieved 2021-01-02.
  19. Iowa, Internal Medicine at (2020-03-04). "Abel named APM president-elect". Making the Rounds. Retrieved 2021-01-02.
  20. Scholars, The Community of. "1,000 inspiring Black scientists in America". crosstalk.cell.com. Retrieved 2021-01-02.
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