EDEM2

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene.[5][6][7]

EDEM2
Identifiers
Aliases	EDEM2, C20orf31, C20orf49, bA4204.1, ER degradation enhancing alpha-mannosidase like protein 2
External IDs	OMIM: 610302 MGI: 1915540 HomoloGene: 10075 GeneCards: EDEM2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,115,364 bp[1] End 35,147,336 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,701,677 bp[2] End 155,729,475 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • catalytic activity Cellular component • endoplasmic reticulum lumen • endoplasmic reticulum • membrane • endoplasmic reticulum quality control compartment Biological process • endoplasmic reticulum unfolded protein response • mannose trimming involved in glycoprotein ERAD pathway • N-glycan processing • positive regulation of retrograde protein transport, ER to cytosol • response to unfolded protein • ubiquitin-dependent glycoprotein ERAD pathway • trimming of terminal mannose on B branch • trimming of terminal mannose on C branch • trimming of first mannose on A branch • trimming of second mannose on A branch Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55741	108687
Ensembl	ENSG00000088298	ENSMUSG00000038312
UniProt	Q9BV94	Q8BJT9
RefSeq (mRNA)	NM_001145025 NM_018217	NM_145537
RefSeq (protein)	NP_001138497 NP_060687	NP_663512
Location (UCSC)	Chr 20: 35.12 – 35.15 Mb	Chr 2: 155.7 – 155.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000088298 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038312 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
6. Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
7. "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.