EDF1

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[5][6][7]

EDF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X57
Identifiers
Aliases	EDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs	OMIM: 605107 MGI: 1891227 HomoloGene: 2809 GeneCards: EDF1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,862,119 bp[1] End 136,866,308 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,557,847 bp[2] End 25,562,082 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • calmodulin binding • histone acetyltransferase activity • GO:0001948 protein binding • RNA binding • TFIID-class transcription factor binding Cellular component • cytoplasm • transcription factor TFIID complex • intracellular • nucleolus • extracellular exosome • cell nucleus • cytosol Biological process • cell differentiation • regulation of transcription, DNA-templated • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • regulation of lipid metabolic process • endothelial cell differentiation • positive regulation of DNA binding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8721	59022
Ensembl	ENSG00000107223	ENSMUSG00000015092
UniProt	O60869	Q9JMG1
RefSeq (mRNA)	NM_153200 NM_001281297 NM_001281298 NM_001281299 NM_003792	NM_021519
RefSeq (protein)	NP_001268226 NP_001268227 NP_001268228 NP_003783 NP_694880	NP_067494
Location (UCSC)	Chr 9: 136.86 – 136.87 Mb	Chr 2: 25.56 – 25.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[7]

Interactions

EDF1 has been shown to interact with:

• Liver X receptor alpha,[8]
• Peroxisome proliferator-activated receptor gamma,[8] and
• TATA binding protein.[8][9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000107223 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015092 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
6. Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053. S2CID 861006.
7. "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
8. Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
9. Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
10. Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

Further reading

• Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. doi:10.1128/mcb.14.5.3013. PMC 358669. PMID 8164657.
• Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells. 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174. S2CID 17825943.
• Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
• Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene. 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.