EDIL3

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene. [5]

EDIL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D90
Identifiers
Aliases	EDIL3, DEL1, EGF like repeats and discoidin domains 3
External IDs	OMIM: 606018 MGI: 1329025 HomoloGene: 21166 GeneCards: EDIL3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.3 Start 83,940,554 bp[1] End 84,384,880 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 88,821,472 bp[2] End 89,323,223 bp[2]
Gene ontology Molecular function • calcium ion binding • integrin binding • metal ion binding • extracellular matrix structural constituent Cellular component • extracellular vesicle • extracellular region • extracellular exosome • extracellular matrix • collagen-containing extracellular matrix Biological process • multicellular organism development • cell adhesion • positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10085	13612
Ensembl	ENSG00000164176	ENSMUSG00000034488
UniProt	O43854	O35474
RefSeq (mRNA)	NM_001278642 NM_005711	NM_001037987 NM_010103
RefSeq (protein)	NP_001265571 NP_005702	NP_001033076 NP_034233
Location (UCSC)	Chr 5: 83.94 – 84.38 Mb	Chr 13: 88.82 – 89.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.

References

1. GRCh38: Ensembl release 89: ENSG00000164176 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034488 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EGF like repeats and discoidin domains 3". Retrieved 2017-07-24.

Further reading

• Rezaee M, Penta K, Quertermous T (2002). "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3)". Am. J. Physiol. Heart Circ. Physiol. 282 (5): H1924–32. doi:10.1152/ajpheart.00921.2001. PMID 11959660.
• Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T (2002). "The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation". Microvascular Research. 64 (1): 148–61. doi:10.1006/mvre.2002.2414. PMID 12074641.
• Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur. J. Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.
• Zou X, Qiao H, Jiang X, Dong X, Jiang H, Sun X (2009). "Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer". J. Biomed. Sci. 16: 33. doi:10.1186/1423-0127-16-33. PMC 2666667. PMID 19292890.
• Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK (2009). "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations". Hum. Genet. 126 (5): 655–66. doi:10.1007/s00439-009-0714-x. PMC 2783187. PMID 19578876.
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Sun JC, Liang XT, Pan K, Wang H, Zhao JJ, Li JJ, Ma HQ, Chen YB, Xia JC (2010). "High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients". World J. Gastroenterol. 16 (36): 4611–5. doi:10.3748/wjg.v16.i36.4611. PMC 2945496. PMID 20857535.
• Glessner JT, Bradfield JP, Wang K, Takahashi N, Zhang H, Sleiman PM, Mentch FD, Kim CE, Hou C, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz RI, Hakonarson H, Grant SF (2010). "A genome-wide study reveals copy number variants exclusive to childhood obesity cases". Am. J. Hum. Genet. 87 (5): 661–6. doi:10.1016/j.ajhg.2010.09.014. PMC 2978976. PMID 20950786.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.