ELMO2

Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene.[5][6]

ELMO2
Identifiers
Aliases	ELMO2, CED-12, CED12, ELMO-2, Ced-12A, engulfment and cell motility 2, VMPI
External IDs	OMIM: 606421 MGI: 2153045 HomoloGene: 44338 GeneCards: ELMO2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,366,050 bp[1] End 46,432,985 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 165,288,031 bp[2] End 165,326,479 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • receptor tyrosine kinase binding • GO:0001948 protein binding Cellular component • cytosol • membrane • cytoplasm Biological process • cell chemotaxis • vascular endothelial growth factor receptor signaling pathway • cell-cell adhesion • cell migration • cytoskeleton organization • Fc-gamma receptor signaling pathway involved in phagocytosis • phagocytosis • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63916	140579
Ensembl	ENSG00000062598	ENSMUSG00000017670
UniProt	Q96JJ3 Q5JVZ4	Q8BHL5
RefSeq (mRNA)	NM_022086 NM_133171 NM_182764 NM_001318253	NM_080287 NM_207705 NM_207706 NM_001302752 NM_001302754
RefSeq (protein)	NP_001305182 NP_573403 NP_877496	NP_001289681 NP_001289683 NP_525026 NP_997589
Location (UCSC)	Chr 20: 46.37 – 46.43 Mb	Chr 2: 165.29 – 165.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000062598 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017670 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS (Oct 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration" (PDF). Cell. 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183. S2CID 15232864.
6. "Entrez Gene: ELMO2 engulfment and cell motility 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Zhou Z, Caron E, Hartwieg E, et al. (2001). "The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway". Dev. Cell. 1 (4): 477–89. doi:10.1016/S1534-5807(01)00058-2. PMID 11703939.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo". Nature. 424 (6947): 461–4. doi:10.1038/nature01817. PMID 12879077. S2CID 4411133.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Castelo R, Reymond A, Wyss C, et al. (2005). "Comparative gene finding in chicken indicates that we are closing in on the set of multi-exonic widely expressed human genes". Nucleic Acids Res. 33 (6): 1935–9. doi:10.1093/nar/gki328. PMC 1074396. PMID 15809229.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.