ENAH (gene)

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.[5][6]

ENAH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HO2, 2IYB, 2XQN, 4MY6
Identifiers
Aliases	ENAH, ENA, MENA, NDPP1, enabled homolog (Drosophila), actin regulator
External IDs	OMIM: 609061 MGI: 108360 HomoloGene: 134005 GeneCards: ENAH
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 225,486,835 bp[1] End 225,653,142 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H5|1 84.93 cM Start 181,896,384 bp[2] End 182,019,990 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • WW domain binding • actin binding • GO:0001948 protein binding • profilin binding Cellular component • filopodium • cell junction • cell membrane • cell projection • synapse • cytoskeleton • focal adhesion • lamellipodium • cytoplasm • cytosol Biological process • axon guidance • actin polymerization or depolymerization • actin polymerization-dependent cell motility Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55740	13800
Ensembl	ENSG00000154380	ENSMUSG00000022995
UniProt	Q8N8S7	Q03173
RefSeq (mRNA)	NM_001008493 NM_018212	NM_001083120 NM_001083121 NM_008680 NM_010135
RefSeq (protein)	NP_001008493 NP_060682 NP_001364410 NP_001364411 NP_001364412	NP_001076589 NP_001076590 NP_032706 NP_034265
Location (UCSC)	Chr 1: 225.49 – 225.65 Mb	Chr 1: 181.9 – 182.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ENAH (gene) has been shown to interact with ABI1[7] and ZYX.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (December 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta. 1132 (3): 240–8. doi:10.1016/0167-4781(92)90156-t. hdl:2027.42/29785. PMID 1420303.
6. "Entrez Gene: ENAH enabled homolog (Drosophila)".
7. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
8. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.

Further reading

• Niebuhr K, Ebel F, Frank R, et al. (1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family". EMBO J. 16 (17): 5433–44. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
• Ermekova KS, Zambrano N, Linn H, et al. (1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
• Mammoto A, Sasaki T, Asakura T, et al. (1998). "Interactions of drebrin and gephyrin with profilin". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
• Geese M, Schlüter K, Rothkegel M, et al. (2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed". J. Cell Sci. 113 (8): 1415–26. PMID 10725224.
• Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
• Drees B, Friederich E, Fradelizi J, et al. (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
• Krugmann S, Jordens I, Gevaert K, et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. S2CID 11290377.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Tani K, Sato S, Sukezane T, et al. (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
• Garvalov BK, Higgins TE, Sutherland JD, et al. (2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". J. Cell Biol. 161 (1): 33–9. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
• Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
• Giesemann T, Schwarz G, Nawrotzki R, et al. (2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system". J. Neurosci. 23 (23): 8330–9. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687. PMID 12967995.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Stüven T, Hartmann E, Görlich D (2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". EMBO J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
• Di Modugno F, Bronzi G, Scanlan MJ, et al. (2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response". Int. J. Cancer. 109 (6): 909–18. doi:10.1002/ijc.20094. PMID 15027125.
• Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
• Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.