EPS8L1

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.[5][6]

EPS8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Aliases	EPS8L1, DRC3, EPS8R1, PP10566, EPS8 like 1
External IDs	OMIM: 614987 MGI: 1914675 HomoloGene: 15767 GeneCards: EPS8L1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,072,020 bp[1] End 55,087,923 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,460,674 bp[2] End 4,480,487 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • actin binding • T cell receptor binding • GO:0001948 protein binding • cadherin binding Cellular component • ruffle membrane • extracellular exosome • cytoplasm • cytosol • cell membrane • macromolecular complex Biological process • regulation of Rho protein signal transduction • Rho protein signal transduction • positive regulation of ruffle assembly • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54869	67425
Ensembl	ENSG00000131037	ENSMUSG00000006154
UniProt	Q8TE68	Q8R5F8
RefSeq (mRNA)	NM_017729 NM_133180 NM_139204	NM_001290416 NM_026146 NM_001374622
RefSeq (protein)	NP_060199 NP_573441	NP_001277345 NP_080422 NP_001361551
Location (UCSC)	Chr 19: 55.07 – 55.09 Mb	Chr 7: 4.46 – 4.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000131037 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006154 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
6. "Entrez Gene: EPS8L1 EPS8-like 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu K, Xu Z, Wang M, et al. (1999). "[Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 16 (5): 325–7. PMID 10514543.