EPS8L3

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.[5][6]

EPS8L3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXT
Identifiers
Aliases	EPS8L3, EPS8R3, EPS8 like 3, HYPT5
External IDs	OMIM: 614989 MGI: 2139743 HomoloGene: 15878 GeneCards: EPS8L3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,750,080 bp[1] End 109,764,027 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,877,229 bp[2] End 107,892,900 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • Rac guanyl-nucleotide exchange factor activity • actin filament binding • actin binding Cellular component • cytoplasm • cell membrane • ruffle membrane Biological process • regulation of hair cycle • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79574	99662
Ensembl	ENSG00000198758	ENSMUSG00000040600
UniProt	Q8TE67	Q91WL0
RefSeq (mRNA)	NM_024526 NM_133181 NM_139053 NM_001319952	NM_133867
RefSeq (protein)	NP_001306881 NP_078802 NP_573444 NP_620641	NP_598628
Location (UCSC)	Chr 1: 109.75 – 109.76 Mb	Chr 3: 107.88 – 107.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198758 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040600 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
6. "Entrez Gene: EPS8L3 EPS8-like 3".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.