EXPH5

Exophilin 5, also known as EXPH5, is a human gene.[5]

EXPH5
Identifiers
Aliases	EXPH5, SLAC2-B, SLAC2B, exophilin 5
External IDs	OMIM: 612878 MGI: 2443248 HomoloGene: 9007 GeneCards: EXPH5
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 108,505,435 bp[1] End 108,593,768 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 53,301,670 bp[2] End 53,377,514 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rab GTPase binding Cellular component • endosome Biological process • positive regulation of exocytosis • keratinocyte development • intracellular protein transport • multivesicular body sorting pathway • positive regulation of protein secretion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23086	320051
Ensembl	ENSG00000110723	ENSMUSG00000034584
UniProt	Q8NEV8	Q0VAV2
RefSeq (mRNA)	NM_001144763 NM_001144764 NM_001144765 NM_001308019 NM_015065	NM_176846
RefSeq (protein)	NP_001138235 NP_001138236 NP_001138237 NP_001294948 NP_055880	NP_789816
Location (UCSC)	Chr 11: 108.51 – 108.59 Mb	Chr 9: 53.3 – 53.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EXPH5 has been shown to interact with RAB27A.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000110723 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034584 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EXPH5 exophilin 5".
6. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.

Further reading

• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
• Fukuda M (2002). "Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A". J. Biol. Chem. 277 (42): 40118–24. doi:10.1074/jbc.M205765200. PMID 12189142.
• Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. doi:10.1016/S0014-5793(02)02634-0. PMID 12062444. S2CID 14844547.
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.