Earl Davie

Earl Warren Davie (October 25, 1927 - June 6, 2020) was an American biochemist. He was a professor emeritus of biochemistry at the University of Washington. Davie studied the blood proteins involved in coagulation and was among the first scientists to describe the steps of the clotting process. He was a member of the National Academy of Sciences and a fellow of the American Academy of Arts and Sciences.[1]

Earl W. Davie
Born(1927-10-25)October 25, 1927
Tacoma, Washington
DiedJune 6, 2020(2020-06-06) (aged 92)
Bellevue, Washington
EducationUniversity of Washington (B.S., Ph.D.)
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Washington

Early life

Davie was born on October 25, 1927 in Tacoma, Washington,[2] to Charles and Teckla Davie. He grew up in La Grande, Washington and attended Eatonville High School.[3] He received an undergraduate degree in 1950 from the University of Washington, where he had worked in the laboratory of biochemistry professor Donald Hanahan.[4] He completed a Ph.D. at UW in 1954.[5] During his doctoral studies, Davie worked with Hans Neurath to learn about protein structure and function.[4]

Career

After a postdoctoral fellowship with Fritz Lipmann at Harvard Medical School, Davie worked at the Case Western Reserve University School of Medicine from 1957 to 1962, where he met hematologist Oscar Ratnoff, the discoverer of Hageman factor (later known as factor XII). He then returned to the University of Washington, later chairing the biochemistry department for several years.[6]

Davie has made significant research contributions to the understanding of coagulation. Davie and Ratnoff described the sequence of steps in the clotting cascade. Davie and Ratnoff published their clotting cascade model in 1964, around the same time that Robert Gwyn Macfarlane of the University of Oxford produced a similar model.[7] Davie cofounded a biotechnology company, ZymoGenetics, in 1981. The company was purchased by Novo Nordisk several years later; in 2000, ZymoGenetics was recreated as an independent company and it was acquired by Bristol-Myers Squibb in 2010.[8]

Honors and awards

In 1980, Davie was elected to the National Academy of Sciences.[9] He was named a fellow of the American Academy of Arts and Sciences in 1987.[10] In 1993, Davie awarded the Stratton Medal from the American Society of Hematology; he was named a Legend in Hematology by the society in 2008.[11] He received a Distinguished Achievement Award from the American Heart Association in 1995.[12] The Centre for Blood Research at the University of British Columbia established the Earl W. Davie Symposium in his honor.[13]

References
  1. "Earl Davie, co-founder of ZymoGenetics and pioneer in blood-clotting research, dies at 93". The Seattle Times. Retrieved 1 October 2020.
  2. "1962: Blood Coagulation". UW Office of Research. November 1996. Archived from the original on August 25, 2015. Retrieved November 12, 2015.
  3. https://www.flintofts.com/obituary/Earl-Warren-Davie/Clyde-Hill-WA/1874870
  4. Kresge, Nicole; Simoni, Robert; Hill, Robert (December 1, 2006). "The waterfall sequence for blood clotting: The work of Earl W. Davie". Journal of Biological Chemistry. 281 (48): e39. doi:10.1016/S0021-9258(20)72075-2. Retrieved November 12, 2015.
  5. "Earl Davie". University of Washington. Retrieved November 12, 2015.
  6. "Earl W Davie, MD, PhD". Vallee Foundation. Retrieved November 12, 2015.
  7. Caen, Jacques; Wu, Qingyu (August 2010). "Hageman factor, platelets and polyphosphates: Early history and recent connection". Journal of Thrombosis and Haemostasis. 8 (8): 1670–1674. doi:10.1111/j.1538-7836.2010.03893.x. PMC 2965785. PMID 20456750.
  8. "ZymoGenetics, a Bristol-Myers Squibb Company". Bristol-Myers Squibb. Retrieved November 12, 2015.
  9. "Earl W. Davie". National Academy of Sciences. Retrieved November 12, 2015.
  10. "Dr. Earl W. Davie". American Academy of Arts and Sciences. Retrieved November 12, 2015.
  11. "Legends in Hematology". American Society of Hematology. Retrieved November 12, 2015.
  12. "Earl W Davie, MD, PhD | The Vallee Foundation". www.thevalleefoundation.org. Retrieved May 17, 2020.
  13. "Earl W. Davie Symposium". Centre for Blood Research. Retrieved November 12, 2015.
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