Elaine Mardis

Elaine R. Mardis (born September 28, 1962) is the co-executive director of the Institute for Genomic Medicine at Nationwide Children's Hospital, where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine.[1] She also is professor of pediatrics at the Ohio State University College of Medicine.[2] Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine.[3] She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome,[4][5] and participated extensively in The Cancer Genome Atlas (TCGA) and the Pediatric Cancer Genome Project (PCGP).[3][6][7][8]

Elaine Mardis
Scientific career
InstitutionsMcDonnell Genome Institute
Washington University School of Medicine
University of Oklahoma
Bio-Rad Laboratories

Biography

Mardis was born in North Platte, Nebraska. She gained a passion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this passion.[9][10]

She received her undergraduate degree in Zoology from the University of Oklahoma in 1984.[1] During her senior year she took a course in biochemistry that was taught by Bruce Roe, PhD, which says opened her eyes to the world of molecular biology.[9] She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr. Roe, who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory.[10] As a result, during her doctoral work Mardis learned the art of DNA sequencing, at a time when few others were doing this.[9][10]

After obtaining her PhD in chemistry and biochemistry in 1989, Mardis did postgraduate work in industry at Bio-Rad Laboratories in Hercules, California.[1]

In 1993, Mardis joined the faculty of Washington University School of Medicine.[1] Over the next 23 years, she held several and academic and leadership roles at the University, including serving as co-director of the McDonnell Genome Institute.[3] In that position, she contributed substantially to the sequencing and analysis of the human genome,[11] and was instrumental in establishing the utility of massively parallel sequencing technologies for understanding cancer biology.[3] Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer, including acute myeloid leukemia,[7][12][13] breast cancer,[14][15] glioblastoma,[16] and lung adenocarcinoma.[17][18] By better defining the landscape of germline and somatic alterations, this research helps drive new strategies for treating cancer, and is central to the concept of precision medicine.

Since joining Nationwide Children's Hospital in 2016, Dr. Mardis has turned the focus of her research to the incorporation of next-generation sequencing assays and established knowledge about cancer genomics into clinical and therapeutic decision-making, and into the design of new approaches to cancer immunotherapy.[3][19][20]

In 2015, Mardis helped launch an open access, precision medicine journal, Molecular Case Studies, in conjunction with Cold Spring Harbor Laboratory Press.[21] She currently serves as Editor-in-Chief.[22]

Mardis was elected as president of the American Association for Cancer Research for 2019–2020.[23]

Awards and honors
  • 2010: Scripps Translational Research Award[3]
  • 2011: Distinguished Alumna Award from the College of Arts and Sciences, Oklahoma University[24]
  • 2016: Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American Association for Clinical Chemistry[25]
  • 2017: Precision Medicine World Congress 2017 Luminary Award[26]
  • 2019: Elected to the 2019 class of Fellows of the American Association for Cancer Research (AACR) Academy[27]

References
  1. "Nationwide Children's Hospital: Find a Doctor". Retrieved May 1, 2019.
  2. "The Lantern". Retrieved May 1, 2019.
  3. "PMWC Speaker Biography". Retrieved May 1, 2019.
  4. Ley, Timothy J.; Mardis, Elaine R.; Ding, Li; Fulton, Bob; McLellan, Michael D.; Chen, Ken; Dooling, David; Dunford-Shore, Brian H.; McGrath, Sean; Hickenbotham, Matthew; Cook, Lisa; Abbott, Rachel; Larson, David E.; Koboldt, Dan C.; Pohl, Craig; Smith, Scott; Hawkins, Amy; Abbott, Scott; Locke, Devin; Hillier, Ladeana W.; Miner, Tracie; Fulton, Lucinda; Magrini, Vincent; Wylie, Todd; Glasscock, Jarret; Conyers, Joshua; Sander, Nathan; Shi, Xiaoqi; Osborne, John R.; et al. (2008). "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome". Nature. 456 (7218): 66–72. Bibcode:2008Natur.456...66L. doi:10.1038/nature07485. PMC 2603574. PMID 18987736.
  5. Grady, Denise (November 6, 2008). ""Scientists Decode Set of Cancer Genes." New York Times, November 5, 2008". The New York Times. The New York Times Company. Retrieved May 1, 2019.
  6. "The Cancer Genome Atlas Timeline & Milestones". National Cancer Institute. 2018-06-13. Retrieved May 1, 2019.
  7. Cancer Genome Atlas Research Network; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–1068. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
  8. Zhang, J.; Wu, G.; Miller, C. P.; Tatevossian, R. G.; Dalton, J. D.; Tang, B.; Orisme, W.; Punchihewa, C.; Parker, M.; Qaddoumi, I.; Boop, F. A.; Lu, C.; Kandoth, C.; Ding, L.; Lee, R.; Huether, R.; Chen, X.; Hedlund, E.; Nagahawatte, P.; Rusch, M.; Boggs, K.; Cheng, J.; Becksfort, J.; Ma, J.; Song, G.; Li, Y.; Wei, L.; Wang, J.; Shurtleff, S.; et al. (2013). "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas". Nature Genetics. 45 (6): 602–612. doi:10.1038/ng.2611. PMC 3727232. PMID 23583981.
  9. Mardis, E.; Dhillon, P. (2014). "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis". Disease Models & Mechanisms. 7 (3): 313–317. doi:10.1242/dmm.015396. PMC 3944491. PMID 24609032.
  10. Arbanas, Caroline (September 10, 2008). "Genome technology wizard". The Source, Washington University in Saint Louis. Retrieved May 1, 2019.
  11. Purddy, Michael C. (October 21, 2004). "Genome center is major contributor to 'finished' human genome sequence". Washington University in St. Louis. Retrieved May 1, 2019.
  12. Mardis, Elaine R.; Ding, Li; Dooling, David J.; Larson, David E.; McLellan, Michael D.; Chen, Ken; Koboldt, Daniel C.; Fulton, Robert S.; Delehaunty, Kim D.; McGrath, Sean D.; Fulton, Lucinda A.; Locke, Devin P.; Magrini, Vincent J.; Abbott, Rachel M.; Vickery, Tammi L.; Reed, Jerry S.; Robinson, Jody S.; Wylie, Todd; Smith, Scott M.; Carmichael, Lynn; Eldred, James M.; Harris, Christopher C.; Walker, Jason; Peck, Joshua B.; Du, Feiyu; Dukes, Adam F.; Sanderson, Gabriel E.; Brummett, Anthony M.; Clark, Eric; et al. (2009). "Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome". The New England Journal of Medicine. 361 (11): 1058–1066. doi:10.1056/NEJMoa0903840. PMC 3201812. PMID 19657110.
  13. Ding, Li; Ley, Timothy J.; Larson, David E.; Miller, Christopher A.; Koboldt, Daniel C.; Welch, John S.; Ritchey, Julie K.; Young, Margaret A.; Lamprecht, Tamara; McLellan, Michael D.; McMichael, Joshua F.; Wallis, John W.; Lu, Charles; Shen, Dong; Harris, Christopher C.; Dooling, David J.; Fulton, Robert S.; Fulton, Lucinda L.; Chen, Ken; Schmidt, Heather; Kalicki-Veizer, Joelle; Magrini, Vincent J.; Cook, Lisa; McGrath, Sean D.; Vickery, Tammi L.; Wendl, Michael C.; Heath, Sharon; Watson, Mark A.; Link, Daniel C.; et al. (2012). "Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing". Nature. 481 (7382): 506–10. Bibcode:2012Natur.481..506D. doi:10.1038/nature10738. PMC 3267864. PMID 22237025.
  14. Ellis, Matthew J.; Ding, Li; Shen, Dong; Luo, Jingqin; Suman, Vera J.; Wallis, John W.; Van Tine, Brian A.; Hoog, Jeremy; Goiffon, Reece J.; Goldstein, Theodore C.; Ng, Sam; Lin, Li; Crowder, Robert; Snider, Jacqueline; Ballman, Karla; Weber, Jason; Chen, Ken; Koboldt, Daniel C.; Kandoth, Cyriac; Schierding, William S.; McMichael, Joshua F.; Miller, Christopher A.; Lu, Charles; Harris, Christopher C.; McLellan, Michael D.; Wendl, Michael C.; Deschryver, Katherine; Allred, D. Craig; Esserman, Laura; et al. (2012). "Whole-genome analysis informs breast cancer response to aromatase inhibition". Nature. 486 (7403): 353–60. Bibcode:2012Natur.486..353E. doi:10.1038/nature11143. PMC 3383766. PMID 22722193.
  15. Griffith, Obi L.; Spies, Nicholas C.; Anurag, Meenakshi; Griffith, Malachi; Luo, Jingqin; Tu, Dongsheng; Yeo, Belinda; Kunisaki, Jason; Miller, Christopher A.; Krysiak, Kilannin; Hundal, Jasreet; Ainscough, Benjamin J.; Skidmore, Zachary L.; Campbell, Katie; Kumar, Runjun; Fronick, Catrina; Cook, Lisa; Snider, Jacqueline E.; Davies, Sherri; Kavuri, Shyam M.; Chang, Eric C.; Magrini, Vincent; Larson, David E.; Fulton, Robert S.; Liu, Shuzhen; Leung, Samuel; Voduc, David; Bose, Ron; Dowsett, Mitch; et al. (2018). "The prognostic effects of somatic mutations in ER-positive breast cancer". Nature Communications. 9 (1): 3476. Bibcode:2018NatCo...9.3476G. doi:10.1038/s41467-018-05914-x. PMC 6123466. PMID 30181556.
  16. McLendon, Roger; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–8. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
  17. Ding, Li; Getz, Gad; Wheeler, David A.; Mardis, Elaine R.; McLellan, Michael D.; Cibulskis, Kristian; Sougnez, Carrie; Greulich, Heidi; Muzny, Donna M.; Morgan, Margaret B.; Fulton, Lucinda; Fulton, Robert S.; Zhang, Qunyuan; Wendl, Michael C.; Lawrence, Michael S.; Larson, David E.; Chen, Ken; Dooling, David J.; Sabo, Aniko; Hawes, Alicia C.; Shen, Hua; Jhangiani, Shalini N.; Lewis, Lora R.; Hall, Otis; Zhu, Yiming; Mathew, Tittu; Ren, Yanru; Yao, Jiqiang; Scherer, Steven E.; et al. (2008). "Somatic mutations affect key pathways in lung adenocarcinoma". Nature. 455 (7216): 1069–75. Bibcode:2008Natur.455.1069D. doi:10.1038/nature07423. PMC 2694412. PMID 18948947.
  18. Wagner, Alex H.; Devarakonda, Siddhartha; Skidmore, Zachary L.; Krysiak, Kilannin; Ramu, Avinash; Trani, Lee; Kunisaki, Jason; Masood, Ashiq; Waqar, Saiama N.; Spies, Nicholas C.; Morgensztern, Daniel; Waligorski, Jason; Ponce, Jennifer; Fulton, Robert S.; Maggi, Leonard B.; Weber, Jason D.; Watson, Mark A.; o'Conor, Christopher J.; Ritter, Jon H.; Olsen, Rachelle R.; Cheng, Haixia; Mukhopadhyay, Anandaroop; Can, Ismail; Cessna, Melissa H.; Oliver, Trudy G.; Mardis, Elaine R.; Wilson, Richard K.; Griffith, Malachi; Griffith, Obi L.; Govindan, Ramaswamy (2018). "Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer". Nature Communications. 9 (1): 3787. Bibcode:2018NatCo...9.3787W. doi:10.1038/s41467-018-06162-9. PMC 6141466. PMID 30224629.
  19. Johanns, Tanner M.; Miller, Christopher A.; Liu, Connor J.; Perrin, Richard J.; Bender, Diane; Kobayashi, Dale K.; Campian, Jian L.; Chicoine, Michael R.; Dacey, Ralph G.; Huang, Jiayi; Fritsch, Edward F.; Gillanders, William E.; Artyomov, Maxim N.; Mardis, Elaine R.; Schreiber, Robert D.; Dunn, Gavin P. (2019). "Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma". Oncoimmunology. 8 (4): e1561106. doi:10.1080/2162402x.2018.1561106. PMC 6422384. PMID 30906654.
  20. "Elaine R Mardis, PhD". Ohio State University. Retrieved May 1, 2019.
  21. "Press release. Cold Spring Harbor Laboratory Press" (PDF) (Press release). Retrieved May 1, 2019.
  22. "About Cold Spring Harbor Molecular Case Studies". Retrieved May 1, 2019.
  23. "Elaine R. Mardis, PhD, Named American Association for Cancer Research President-Elect 2018-2019" (Press release). Nationwide Children's Hospital. March 21, 2012. Retrieved May 1, 2019.
  24. "Distinguished Alumni". Oklahoma University. Retrieved May 1, 2019.
  25. "The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics". AACC. Retrieved May 1, 2019.
  26. "PMWC Speaker biography: Awards". Retrieved May 1, 2019.
  27. "American Association for Cancer Research Announces 2019 Class of Fellows of the AACR Academy". AACR. March 25, 2019. Retrieved May 1, 2019.
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