Elizabeth Hillman

Elizabeth M. C. Hillman is a British-born academic who is Professor of Biomedical Engineering and Radiology at Columbia University.[2] She was awarded the 2011 Adolph Lomb Medal from The Optical Society and the 2018 SPIE Biophotonics Technology Innovator Award.

Elizabeth Hillman
Born
Elizabeth Marjorie Clare Hillman
Alma materUniversity College London (BSc, PhD)
AwardsAdolph Lomb Medal (2011)
Scientific career
InstitutionsHarvard Medical School
Columbia University
ThesisExperimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications (2002)
Doctoral advisorJeremy C. Hebden
David Delpy[1]
Websiteorion.bme.columbia.edu/~hillman

Education

Hillman studied physics at University College London, and graduated with a combined B.Sc. and M.Sc. degree in 1998.[3] She earned her PhD in Medical Physics and Bioengineering in 2002.[3] After completing her thesis, supervised by Jeremy C. Hebden and David Delpy,[1] she joined a biotech start-up in Boston.[4][1] During her PhD, she used optical tomography to image biological tissue.[5][6]

Career

Hillman joined Massachusetts General Hospital as a postdoctoral research fellow in 2003. She was appointed assistant professor at Columbia University in 2006.[3] She set up the Laboratory for Functional Optical Imaging and developed new techniques for in vivo optical imaging. She developed an optical imaging technique that used dynamic contrast to image the anatomy of small animals.[7] She licensed this Dynamic Contrast molecular imaging technique to CRi, now PerkinElmer. In 2008 she was awarded the Columbia Rodriguez Junior Faculty Award.[3] She was awarded the Optical Society of America’s Adolph Lomb medal in 2011.[8] In 2010 she was awarded a National Science Foundation Career award to study in vivo Interventional Microscopy.[9] She has explored several optical imaging techniques for biomedical research.[10][11] She has received over thirty large grants to support her research.[12]

In 2017, Hillman began to work at Columbia's Zuckerman Mind Brain Behavior Institute.[3] With Francesco Pavone, Hillman founded The Optical Society Optics and the Brain Topical Meeting in 2015.[13] She identified that the vascular endothelium is important in regulation of blood flow in the brain.[14] She has written for Scientific American.[15] She was elected to the American Institute for Medical and Biological Engineering in 2017.[16] She has developed tools for high speed imaging of the activity in the whole brain.[17] Hillman pioneered Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy, which combines light-sheet microscopy and laser scanning confocal microscopy.[18][19][20] The technique uses a single objective lens to excite and detect fluorescence from a sample.[21] She has also developed laminar optical tomography and advanced applications of two-photon microscopy.[22][23]

Awards and honors

References
  1. Hillman, Elizabeth (2002). Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications (PDF) (PhD thesis). University College London. OCLC 1000838839. EThOS uk.bl.ethos.268884. Retrieved 2018-08-19.
  2. Elizabeth Hillman publications indexed by Google Scholar
  3. "Hillman Lab: Biomedical Engineering: Columbia University: Elizabeth Hillman". orion.bme.columbia.edu. Retrieved 2018-08-20.
  4. "Elizabeth Hillman". datascience.columbia.edu. Retrieved 2018-08-20.
  5. Hebden, Jeremy; Bland, T.; Hillman, Elizabeth M. C.; Gibson, A.; Everdell, N.; Delpy, David T.; Arridge, Simon R.; Douek, M. (2002-04-07). "Optical tomography of the breast using a 32-channel time-resolved imager". Biomedical Topical Meeting (2002), Paper SuE5: SuE5.
  6. Hebden, Jeremy C.; Schmidt, Florian E. W.; Fry, Martin E.; Hillman, Elizabeth M. C.; Schweiger, Martin; Delpy, David T. (1999-06-14). "Imaging of tissue-equivalent phantoms using the UCL multi-channel time-resolved instrument". Biomedical Optics (1999), Paper AMC4: AMC4. doi:10.1364/BIO.1999.AMC4.
  7. Hillman, Elizabeth M. C.; Moore, Anna (2007-08-19). "All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast". Nature Photonics. 1 (9): 526–530. Bibcode:2007NaPho...1..526H. doi:10.1038/nphoton.2007.146. ISSN 1749-4885. PMC 2575379. PMID 18974848.
  8. "Professor Elizabeth Hillman wins OSA Adolph Lomb Medal". bme.columbia.edu. Retrieved 2018-08-20.
  9. "NSF Award Search: Award#0954796 - CAREER: Interventional Microscopy for In-vivo Investigations of Brain Function". www.nsf.gov. Retrieved 2018-08-20.
  10. Hillman, Elizabeth M. C.; Amoozegar, Cyrus B.; Wang, Tracy; McCaslin, Addason F. H.; Bouchard, Matthew B.; Mansfield, James; Levenson, Richard M. (2011-11-28). "In vivo optical imaging and dynamic contrast methods for biomedical research". Phil. Trans. R. Soc. A. 369 (1955): 4620–4643. Bibcode:2011RSPTA.369.4620H. doi:10.1098/rsta.2011.0264. ISSN 1364-503X. PMC 3263788. PMID 22006910.
  11. "Making light work: illuminating the future of biomedical optics | Royal Society". royalsociety.org. Retrieved 2018-08-20.
  12. "Grantome: Search". Grantome. Retrieved 2018-08-20.
  13. "ÜberResearch - Optics and the Brain Topical Meeting". grants.uberresearch.com. Retrieved 2018-08-20.
  14. "Brain power: New insight into how the brain regulates its blood flow". Retrieved 2018-08-20.
  15. Hillman, Elizabeth M. C. (2014-06-12). "Out for Blood". Scientific American Mind. 25 (4): 58–65. doi:10.1038/scientificamericanmind0714-58. ISSN 1555-2284.
  16. "Elizabeth M.C. Hillman to be Inducted into Medical and Biological Engineering Elite" (PDF). AIMBE. Retrieved 2018-08-20.
  17. Center, Laser Biomedical Research (2018-03-19), 2/27/18: Elizabeth M.C. Hillman - "High-speed imaging of whole-brain activity" (3/3), retrieved 2018-08-20
  18. "ÜberResearch - SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organisms". grants.uberresearch.com. Retrieved 2018-08-20.
  19. Yu, Hang; Galwaduge, P. Thilanka; Voleti, Venkatakaushik; Patel, Kripa B.; Shaik, Mohammed A.; Li, Wenze; Hillman, Elizabeth M. C. (2018-04-03). "Combining Near-infrared Excitation with Swept Confocally-aligned Planar Excitation (SCAPE) Microscopy for Fast, Volumetric Imaging in Mouse Brain". Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) (2018), Paper BF3C.3: BF3C.3. doi:10.1364/BRAIN.2018.BF3C.3. ISBN 978-1-943580-41-5.
  20. Bouchard, Matthew B.; Voleti, Venkatakaushik; Mendes, César S.; Lacefield, Clay; Grueber, Wesley B.; Mann, Richard S.; Bruno, Randy M.; Hillman, Elizabeth M. C. (2015-01-19). "Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms". Nature Photonics. 9 (2): 113–119. Bibcode:2015NaPho...9..113B. doi:10.1038/nphoton.2014.323. ISSN 1749-4885. PMC 4317333. PMID 25663846.
  21. "Hillman Lab: Biomedical Engineering: Columbia University: Research". orion.bme.columbia.edu. Retrieved 2018-08-20.
  22. "Women in Optics | Video Interviews | SPIE.org". www.spie.org. Retrieved 2018-08-20.
  23. Hillman, Elizabeth M. C.; Burgess, Sean A. (2009-02-01). "Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography". Laser & Photonics Reviews. 3 (1–2): 159–179. Bibcode:2009LPRv....3..159H. doi:10.1002/lpor.200810031. ISSN 1863-8880. PMC 2763333. PMID 19844595.
  24. "Hillman Lab: Biomedical Engineering: Columbia University: Elizabeth Hillman". orion.bme.columbia.edu. Retrieved 2020-05-10.
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