Elizabeth Nolan

Early life and education

Nolan was born in Niskayuna, New York.[1] She studied at Smith College, where she majored in chemistry and graduated magna cum laude in 2000.[1][2] During her undergraduate studies she minored in music and worked with Robert Linck on computational chemistry.[3] She studied the stereoelectronic effects in substituted alkanes.[4] Nolan was a member of Phi Beta Kappa.[1] She was awarded a Fulbright Program Scholarship and moved to France to study siderophore-iron complexes.[2] Nolan moved to Massachusetts Institute of Technology for her graduate studies, where she was supervised by Stephen J. Lippard.[1] She developed small molecule fluorescent sensors to monitor for zinc in neurobiology and mercury in aqueous solutions.[1][5] Together they filed a patent for Fluorescein-based metal sensors.[6] Nolan was a postdoctoral scientist at the Harvard Medical School, working with Christopher T. Walsh on the biosynthetic assembly of microcin E492m.[7] Microcin E492m is an antibiotic peptide that can target Gram-negative bacteria which express siderophore transporters.[1][7] She was awarded a $2.5 million National Institutes of Health grant in 2010 to study antibacterial peptides and zinc in innate immunity.[8] In 2011 she contributed to the book Letters to a Young Chemist.[4][9]

Research and career

Nolan was appointed as an Assistant Professor at the Department of Chemistry at the Massachusetts Institute of Technology in 2014.[1] She explores the coordination chemistry of metal ions in biological systems; in particular how proteins destroy microbes by denying them metal nutrients.[3][10][11] She looks at the peptides and metalloproteins that are involved in mammalian immune response. Her current focus is on calprotectins and how they bind metals.[12][13] She used magnetic circular dichroism to study the binding of iron to human calprotectin.[14] Her group look to understand how Neuronal cells process and removes SOD1 point mutants.[15]

Nolan looks to design drugs to fight bacterial infections.[10] They study how immunity peptides that are encoded by the gene clusters that biosynthesize antibiotics which use metal ion transporters protect the organisms that produce them.[15] She proposes that hijacking the siderophore uptake pathways could allow new prevention and treatment against diseases.[16] She worked with Manuela Raffatellu at University of California, Irvine to develop a new immunisation strategy against salmonella.[17] They target siderophores, a molecule that salmonella secretes to scavenge iron. Immunisation against siderophores led to the production of antibodies that reduced the growth of salmonella and other bacteria.[18] She is on the editorial board of Cell Chemical Biology.[19]

Patents

Awards and honours

References
  1. "Elizabeth M. Nolan". web.mit.edu. Retrieved 2018-12-23.
  2. "Smith Scholars With Places to Go". www.smith.edu. Retrieved 2018-12-23.
  3. "Chemistry in Action: Liz Nolan | MIT OpenCourseWare | Free Online Course Materials". mit.uvt.rnu.tn. Retrieved 2018-12-24.
  4. Ghosh, Abhik (2011-04-04). Letters to a Young Chemist. John Wiley & Sons. ISBN 9781118007082.
  5. Nolan, Elizabeth M.; Lippard, Stephen J. (2009). "Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry". Accounts of Chemical Research. 42 (1): 193–203. doi:10.1021/ar8001409. ISSN 0001-4842. PMC 2646817. PMID 18989940.
  6. "US Patent for Fluorescein-based metal sensors Patent (Patent # 7,615,377 issued November 10, 2009) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  7. Nolan, Elizabeth M.; Fischbach, Michael A.; Koglin, Alexander; Walsh, Christopher T. (2007). "Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate". Journal of the American Chemical Society. 129 (46): 14336–14347. doi:10.1021/ja074650f. ISSN 0002-7863. PMC 2522288. PMID 17973380.
  8. Nolan, Elizabeth. "Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology". Grantome.
  9. "Letters to a Young Chemist". Wiley.com. Retrieved 2018-12-24.
  10. "Exploring the tug-of-war over metals during infection". MIT News. Retrieved 2018-12-23.
  11. Nolan, Elizabeth. "CAREER: Coordination Chemistry of Zinc-Chelating S100 Proteins and Biochemistry Partnership with a Regional University". Grantome.
  12. "Dr. Elizabeth Nolan - Department of Chemistry & Biochemistry - UMBC". chemistry.umbc.edu. Retrieved 2018-12-23.
  13. MIT OpenCourseWare, Chemistry in Action: Liz Nolan, retrieved 2018-12-23
  14. Baker, Tessa M.; Nakashige, Toshiki G.; Nolan, Elizabeth M.; Neidig, Michael L. (2017). "Magnetic circular dichroism studies of iron(ii) binding to human calprotectin". Chemical Science. 8 (2): 1369–1377. doi:10.1039/c6sc03487j. ISSN 2041-6520. PMC 5361872. PMID 28451278.
  15. "Searle Scholars Program : Elizabeth M. Nolan (2011)". www.searlescholars.net. Retrieved 2018-12-23.
  16. "Elizabeth M Nolan | Massachusetts Institute of Technology, USA | Chronic Diseases 2017 | Pulsus Conference". chronicdiseases.cmesociety.com. Retrieved 2018-12-23.
  17. "A new approach against Salmonella and other pathogens". phys.org. Retrieved 2018-12-24.
  18. Raffatellu, Manuela; Nolan, Elizabeth M.; George, Michael D.; Edwards, Robert A.; Perez-Lopez, Araceli; Zheng, Tengfei; Chairatana, Phoom; Sassone-Corsi, Martina (2016). "Siderophore-based immunization strategy to inhibit growth of enteric pathogens". Proceedings of the National Academy of Sciences. 113 (47): 13462–13467. doi:10.1073/pnas.1606290113. ISSN 1091-6490. PMC 5127304. PMID 27821741.
  19. "Editorial Board: Cell Chemical Biology". www.cell.com. Retrieved 2018-12-23.
  20. "US Patent Application for ENTEROBACTIN CONJUGATES AND USES THEREOF Patent Application (Application #20150105337 issued April 16, 2015) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  21. "US Patent for Enterobactin conjugates and uses thereof Patent (Patent # 9,902,986 issued February 27, 2018) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  22. "US Patent Application for SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA Patent Application (Application #20160022794 issued January 28, 2016) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  23. "US Patent for Siderophore-based immunization against gram-negative bacteria Patent (Patent # 10,039,816 issued August 7, 2018) - Justia Patents Search". patents.justia.com. Retrieved 2018-12-23.
  24. "NIH Director's New Innovator Award - Funded Research". commonfund.nih.gov. Retrieved 2018-12-23.
  25. "Eli Lilly Award in Biological Chemistry" (PDF). ACS Division of Biological Chemistry. Retrieved 2018-12-23.
  26. "Michale Fee and Elizabeth Nolan win Teaching Prizes for Graduate and Undergraduate Education". MIT News. Retrieved 2018-12-23.
  27. Chemistry, Department of; Rd, Biochemistry · 1068 W. Sheridan; Chicago; Copyright, IL 60660 · Phone: 773 508 3100 · Fax: 773 508 3086 ©; Policy, Disclaimer 2018 · Privacy. "Denkewalter Lecture: Chemistry & Biochemistry, Department of : Loyola University Chicago". www.luc.edu. Retrieved 2018-12-23.
  28. "White House honors 19 NSF-supported early-career researchers | NSF - National Science Foundation". www.nsf.gov. Retrieved 2018-12-23.
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