Ellen Heber-Katz

Ellen Heber-Katz is an American immunologist/regeneration biologist who is professor at Lankenau Institute for Medical Research (LIMR).[1] She is an immunologist who investigates mammalian regeneration,[2][3][4][5][6] having discovered the ability of the MRL mouse strain to regenerate wounds without scarring and to fully restore damaged tissues. Her work on regeneration has been extended into National Cancer Institute (NCI)-funded studies of novel aspects of breast cancer causation.[7] Her research interests include immunology, regenerative medicine and cancer.[8]

Ellen Heber-Katz
Born
Philadelphia, Pennsylvania
Alma materUniversity of Pennsylvania (PhD)
University of Wisconsin–Madison (BA)(MS)
AwardsNational Institutes of Health Eureka Grant
National Cancer Institute’s Director’s Provocative Question Initiative Grant
Scientific career
FieldsImmunology, Microbiology
InstitutionsLankenau Institute for Medical Research
The Wistar Institute

Education and career

Heber-Katz earned her B.A. in microbiology and immunology from the University of Wisconsin-Madison, in 1969, and her M.S. in immunology from the same university in 1972.[9] For her M.S. thesis, she studied the role of reducing agents as a critical factor in cellular immune responses.[10] She then moved to Philadelphia to attend the University of Pennsylvania and was awarded her Ph.D. in immunology in 1976. For her doctoral thesis she demonstrated that single T-cell subsets could respond to both histocompatibility antigens and environmental antigens, establishing the unity of these two branches of the immune response.[11] She was a postdoctoral fellow at the National Institutes of Allergy and Infectious Diseases in the Laboratory of Immunology, discovering the first functional evidence for the T cell–antigen-MHC-Ia tri-molecular complex anticipating the crystal structure.

With the use of genetically inbred mice, Heber-Katz and collaborators dissected the fine molecular details that control the T-cell and macrophage interaction. This "A/5R experiment" confirmed the Determinant Selection Hypothesis concerning the spatial relationships between the histocompatibility I-A and I-E molecules on the surface of antigen- presenting cells, the bound antigen and the recognition structure of the T-cell receptor.[12]

References
  1. "Ellen Heber-Katz, PhD - LIMR - Researcher Profile". LIMR. Retrieved 2016-04-02.
  2. Galatz, Leesa M.; Gerstenfeld, Louis; Heber-Katz, Ellen; Rodeo, Scott A. (2015). "Tendon regeneration and scar formation: The concept of scarless healing". Journal of Orthopaedic Research. 33 (6): 823–831. doi:10.1002/jor.22853. PMC 6084432. PMID 25676657.
  3. Zhang, Yong (2015-06-03). "Drug-induced regeneration in adult mice | Science Translational Medicine". Science Translational Medicine. 7 (290): 290ra92. doi:10.1126/scitranslmed.3010228. PMC 4687906. PMID 26041709.
  4. Gourevitch, D; Kossenkov, AV; Zhang, Y; Clark, L; Chang, C; Showe, LC; Heber-Katz, E (2015-09-28). "Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective". Adv Wound Care (New Rochelle). 3 (9): 592–603. doi:10.1089/wound.2014.0528. PMC 4152783. PMID 25207202.
  5. Edwards, RG (2015-09-28). "From embryonic stem cells to blastema and MRL mice". Reprod. Biomed. Online. 16 (3): 425–61. doi:10.1016/S1472-6483(10)60605-0. PMID 18339268.
  6. "Case Closed: A Fluky Finding Raises Hopes for Mending Wounds". Scientific American. Retrieved 2016-04-02.
  7. Nathan A. Berger. Murine Models, Energy Balance, and Cancer: 9783319167329: Medicine & Health Science Books @. ISBN 978-3319167329.
  8. "From Immunity and Vaccines to Mammalian Regeneration". The Journal of Infectious Diseases. 212. 2015. Retrieved 2016-04-03.
  9. "http://www.limr.org/lmr/Page.asp?out=html&searchType=Faculty&PageID=LMR000321"
  10. Click, RE (2015-09-28). "A review: alteration of in vitro reproduction processes by thiols —Emphasis on 2-mercaptoethanol". J. Reprod. Dev. 60 (6): 399–405. doi:10.1262/jrd.2014-055. PMC 4284312. PMID 25087867.
  11. D. B. Wilson; E. Heber-Katz; J. Sprent; J. C. Howard* (1977-01-01). "On the Possibility of Multiple T-cell Receptors". Cold Spring Harbor Symposia on Quantitative Biology. 41: 559–561. doi:10.1101/SQB.1977.041.01.064.
  12. Heber-Katz, E; Hansburg, D; Schwartz, RH (2015-09-28). "The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation". J. Mol. Cell. Immunol. 1 (1): 3–18. PMID 6101061.
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