Enhancer of polycomb homolog 2 (drosophila)

Enhancer of polycomb homolog 2 (Drosophila) is a protein that in humans is encoded by the EPC2 gene.[5]

EPC2
Identifiers
Aliases	EPC2, EPC-LIKE, enhancer of polycomb homolog 2
External IDs	OMIM: 611000 MGI: 1278321 HomoloGene: 32274 GeneCards: EPC2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.1 Start 148,644,440 bp[1] End 148,787,569 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C1.1|2 28.62 cM Start 49,451,486 bp[2] End 49,551,948 bp[2]
Gene ontology Molecular function • histone acetyltransferase activity Cellular component • cell nucleus • NuA4 histone acetyltransferase complex • Piccolo NuA4 histone acetyltransferase complex Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • cellular response to DNA damage stimulus • DNA repair • regulation of transcription from RNA polymerase II promoter • histone acetylation • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26122	227867
Ensembl	ENSG00000135999	ENSMUSG00000069495
UniProt	Q52LR7	Q8C0I4
RefSeq (mRNA)	NM_015630	NM_172663
RefSeq (protein)	NP_056445	NP_766251
Location (UCSC)	Chr 2: 148.64 – 148.79 Mb	Chr 2: 49.45 – 49.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135999 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000069495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Enhancer of polycomb homolog 2 (Drosophila)".

Further reading

• Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (January 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
• Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (October 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi:10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
• Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (January 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi:10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
• Doyon Y, Selleck W, Lane WS, Tan S, Côté J (March 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (April 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi:10.1242/jcs.060178. PMC 2844321. PMID 20332121.
• Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (May 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
• Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (June 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
• Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi:10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
• Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (May 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10.1038/leu.2013.316. PMC 3998875. PMID 24166297.