Eva Feldman

Eva Lucille Feldman, M.D., Ph.D., F.A.A.N., F.A.N.A.[1] is an American physician and the Russell N. DeJong Professor of Neurology at the University of Michigan. She is the Director of the NeuroNetwork for Emerging Therapies and Director of the University of Michigan ALS Center of Excellence, which includes the Pranger ALS Clinic.

For American child actress, see Eva Lee Kuney.

Feldman is one of the world’s leading authorities on neurologic diseases. Her primary interests include amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and neurologic complications of diabetes and obesity, as well as how environmental toxins affect the nervous system. She is annually listed in Best Doctors in America[2] and is a member of the Association of American Physicians (AAP), National Academy of Medicine (NAM) and a Fellow of the American Association for the Advancement of Science (AAAS). Feldman has authored over 470 articles and has received numerous awards and honors throughout her remarkable career.[3]

Early life and education

Growing up in Indiana, Feldman began her academic career at Earlham College, completed her B.A. in biology, and then at the University of Notre Dame, receiving an M.S. in zoology. Her time at U-M began by receiving a Ph.D. (1979) in neuroscience, working in the laboratory of Dr. Bernard Agranoff, and then an M.D. (1983) at U-M Medical School. She performed her residency in neurology (1988) at The Johns Hopkins Hospital where she was named chief resident and the first neurologist to receive The Johns Hopkins Award for Medical Teaching and Excellence. She returned to U-M to complete a fellowship in neuromuscular disease (1988) with longtime mentor Dr. Jim Albers and has remained on faculty ever since.[3]

  • B.A. - Biology, Earlham College (1973)
  • M.S. - Zoology, University of Notre Dame (1975)
  • Ph.D. - Neuroscience, University of Michigan (1979)
  • M.D. - Neuroscience, University of Michigan (1983)
  • Resident - Neurology, The Johns Hopkins Hospital (1987)
  • Fellow - Neuromuscular Disease, University of Michigan (1988)

Career

In 1988, Feldman became an assistant professor and opened her basic science laboratory in the Department of Neurology at Michigan Medicine, serving as member of the Neuroscience Program and Michigan Diabetes Research and Training Center. She was appointed to the faculty of the U-M Cancer Center in 1992. In 1994, she became an associate professor, and in 1998, she joined the faculty of the Cellular and Molecular Biology Program.

In 2000, Feldman became Director of the Juvenile Diabetes Research Foundation Center for the Study of Complications in Diabetes (until 2010), Director of the ALS Center of Excellence at Michigan Medicine, and a fully endowed professor, the Russell N. DeJong Professor of Neurology. In 2005, she was named the Director of Michigan Medicine’s Neuropathy Center. She was appointed the inaugural Director of the A. Alfred Taubman Medical Research Institute in 2007, after U-M received a $100-million-dollar gift from A. Alfred Taubman. She remained Director for a decade.[4]

Feldman served as President of the Peripheral Nerve Society from 2007-2009 and President of the American Neurological Association (ANA) from 2011-2013. At that time, she was only the third woman elected as ANA President in 130 years. She is the only U-M alumnus to receive both Early and Distinguished Career Achievement Awards from the U-M Medical Alumni Society.[5] Among her many honors, Feldman is an elected member of the AAP and NAM and is an AAAS Fellow. As of 2020, she chairs the NAM Neurology and Psychiatry Sections of the NAM.  Feldman also serves on a number of editorial boards for leading scientific journals, including The Lancet Neurology, Nature Neurology, JAMA Neurology, and Journal of Neurology, Neurosurgery and Psychiatry.[3]

Among Feldman’s greatest accomplishments is guiding and supporting the future of medical science through mentoring and inspiring the next generation of scientists and physicians. Nine scientists have received their Ph.D. degrees under her tutelage, and she has trained more than 100 postdoctoral fellows and neurologists to specialize in the understanding and treatment of neurological diseases.[3]

A. Alfred Taubman Medical Research Institute

In January 2007, Feldman was named the first director of the A. Alfred Taubman Medical Research Institute, which was founded by philanthropist A. Alfred Taubman to empower medical scientists to expand the boundaries of discovery, to develop new therapies for disease, and to alleviate human suffering. Under her leadership, the Taubman Institute funded senior-level physician scientists in a diverse spectrum of diseases: adult and childhood cancer, ALS, diabetes, cardiovascular disease, and hearing loss. She also established an Emerging Scholars program to support promising early-career physician scientists. She remained director until 2017.[4]

In 2008, Feldman and the Taubman Institute played an important role in educating Michigan citizens on the importance of stem cell research in the study and treatment of disease. In the November 2008 election, voters approved a constitutional amendment lifting restrictions on stem cell research in the state. As a result of the election, the Taubman Institute opened the first core facility in Michigan dedicated to the derivation of embryonic stem cell lines, one of the few in the nation.

Feldman has made contributions to medical research and clinical care in many critical areas, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease and complications in diabetes. She developed a clinical screening instrument for the rapid diagnosis of diabetic neuropathy,[6] which is currently being used worldwide. She conducted the first human clinical trial of a stem cell therapy for ALS.[7]

NeuroNetwork for Emerging Therapies

Feldman’s scientific laboratory was initially established in 1988, and in 2000 had grown to include over 20 scientists and was named the Program for Neurology Research and Discovery. In the proceeding 20 years, her lab grew to over 30 scientists and was renamed The NeuroNetwork for Emerging Therapies (www.mneuronet.org) in 2020. The mission of Feldman’s research remains the same: to advance scientific discovery and establish therapies for neurological diseases.

Medical Achievements:

Feldman has made contributions to biomedical research and clinical care in many critical areas of neurodegenerative disease.

Feldman is the author of more than 470 articles, 71 book chapters, and four books.[3] Her research has been funded continually by the National Institutes of Health (NIH) for over 30 years, and she currently is the principal investigator or co-Investigator of grants funded by the NIH, Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry, and private foundations. Feldman also leads multiple clinical trials focused on understanding and treating neurological disorders, with an emphasis on ALS and neuropathy.

Representative Honors & Awards

1987       The Johns Hopkins Hospital Annual Resident Award for Outstanding Medical Student Teaching

2000       The Juvenile Diabetes Research Foundation Jane Cobb Promise Award for Medical Research

2001       Michigan Medicine Alumni Society Early Career Distinguished Achievement Award

2002 to present (annual) Castle Connolly

Top Doctors in America

               The Best Doctors in America

               Who’s Who in Medicine and Healthcare

               Who’s Who of American Women

2003, 2005          Juvenile Diabetes Research Foundation Mary Jane Kugel Award

2006       American Diabetes Association Lifetime Achievement Award

2007 to present (annual) America’s Top Doctors

2010       Johns Hopkins Society of Scholars

2011      University of Michigan League of Research Excellence

2012       University of Michigan Distinguished Faculty Achievement Award

2016       Castle Connolly National Physician of the Year Award for Clinical Excellence

Crain’s Detroit Business 100 Most Influential Women in Michigan

Society for Neuroscience Bernice Grafstein Award for Outstanding Accomplishments in Mentoring

2017       Endocrine Society Gerald D. Aurbach Award for Outstanding Translational Research

Esteemed Women of Michigan Recipient

2018       American Neurological Association Honorary Fellow

Marquis Who’s Who in the World Lifetime Award

2019       Peripheral Nerve Society Alan J. Gebhart Prize for Excellence in Peripheral Nerve Research

Michigan Medicine Alumni Society Distinguished Achievement Award

2020       Castle Connolly Exceptional Women in Medicine Award

Sources
  • A. Alfred Taubman Medical Research Institute
  • The University of Michigan Health System
  • The American Neurological Association
  • "Stem cell treatment goes from lab to operating room". CNN. May 4, 2010.
  • "UM researcher to test stem cell treatment for Alzheimer's". Crain's Detroit Business. May 2, 2010.
  • "Celling Out". D Business. March–April 2010.
  • "First U.S. stem cells transplanted into spinal cord". CNN. January 21, 2010.

References
  1. "Eva Lucille Feldman MD | Michigan Medicine". www.uofmhealth.org. Retrieved 2018-09-12.
  2. "National Physician of the Year Award Winner". www.castleconnollyawards.com. Retrieved 2018-08-09.
  3. "Eva L. Feldman, MD, PhD". www.medicine.umich.edu. Retrieved 2021-01-13.
  4. Editor. "Charles Burant appointed as Taubman Institute director". A. Alfred Taubman Medical Research Institute. Retrieved 2021-01-14.CS1 maint: extra text: authors list (link)
  5. "Awards | University of Michigan Medical School Alumni". alumni.medicine.umich.edu. Retrieved 2021-01-14.
  6. Herman, W. H.; Pop-Busui, R.; Braffett, B. H.; Martin, C. L.; Cleary, P. A.; Albers, J. W.; Feldman, E. L. (July 2012). "Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications". Diabetic Medicine : A Journal of the British Diabetic Association. 29 (7): 937–944. doi:10.1111/j.1464-5491.2012.03644.x. ISSN 0742-3071. PMC 3641573. PMID 22417277.
  7. Glass, Jonathan D.; Boulis, Nicholas M.; Johe, Karl; Rutkove, Seward B.; Federici, Thais; Polak, Meraida; Kelly, Crystal; Feldman, Eva L. (June 2012). "Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients". Stem Cells. 30 (6): 1144–1151. doi:10.1002/stem.1079. hdl:2027.42/92063. ISSN 1549-4918. PMID 22415942. S2CID 13356726.

See also
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