FEZ2

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.[5][6]

FEZ2
Identifiers
Aliases	FEZ2, HUM3CL, fasciculation and elongation protein zeta 2
External IDs	OMIM: 604826 MGI: 2675856 HomoloGene: 3742 GeneCards: FEZ2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.2 Start 36,531,805 bp[1] End 36,646,087 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E2|17 48.57 cM Start 78,369,212 bp[2] End 78,418,152 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • axon Biological process • signal transduction • nervous system development • negative regulation of autophagosome assembly • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9637	225020
Ensembl	ENSG00000171055	ENSMUSG00000056121
UniProt	Q9UHY8	Q6TYB5
RefSeq (mRNA)	NM_001042548 NM_005102	NM_001285940 NM_001285946 NM_001285949 NM_199448 NM_001360407
RefSeq (protein)	NP_001036013 NP_005093	NP_001272869 NP_001272875 NP_001272878 NP_955519 NP_001347336
Location (UCSC)	Chr 2: 36.53 – 36.65 Mb	Chr 17: 78.37 – 78.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.[6]

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171055 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
6. "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
7. Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. United States. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.

Further reading

• Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. PMID 8228263.
• Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437. S2CID 6529349.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Fujita T, Ikuta J, Hamada J, et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.