FLVCR1

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1).[5][6][7][8]

FLVCR1
Identifiers
Aliases	FLVCR1, AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1, SLC49A1, FLVCR heme transporter 1
External IDs	OMIM: 609144 MGI: 2444881 HomoloGene: 56661 GeneCards: FLVCR1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 212,858,275 bp[1] End 212,899,363 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 191,005,847 bp[2] End 191,026,158 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transporter activity • GO:0001948 protein binding • heme transporter activity • heme binding Cellular component • integral component of membrane • mitochondrial membranes • membrane • cell membrane • integral component of plasma membrane • mitochondrion Biological process • embryonic skeletal system morphogenesis • head morphogenesis • limb morphogenesis • multicellular organism growth • embryonic digit morphogenesis • in utero embryonic development • mitochondrial transport • spleen development • heme transport • multicellular organism development • blood vessel development • erythrocyte differentiation • regulation of organ growth • heme export • cellular iron ion homeostasis • erythrocyte maturation • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28982	226844
Ensembl	ENSG00000162769	ENSMUSG00000066595
UniProt	Q9Y5Y0	B2RXV4
RefSeq (mRNA)	NM_014053	NM_001081259 NM_001313747 NM_198025
RefSeq (protein)	NP_054772	NP_001074728 NP_001300676 NP_932142
Location (UCSC)	Chr 1: 212.86 – 212.9 Mb	Chr 1: 191.01 – 191.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000162769 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066595 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC 112732. PMID 10400745.
6. Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID 10648427.
7. "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
8. Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN 1474-1784. PMC 5455971. PMID 28154410.

Further reading

• Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene. 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID 11943475.
• Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757–66. doi:10.1016/j.cell.2004.08.014. PMID 15369674. S2CID 12749187.
• Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID 15996880.
• Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC 1367145. PMID 16439531.