FRMD6

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.[5]

FRMD6
Identifiers
Aliases	FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6
External IDs	OMIM: 614555 MGI: 2442579 HomoloGene: 12449 GeneCards: FRMD6
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 51,489,100 bp[1] End 51,730,727 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 70,825,514 bp[2] End 70,902,234 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • structural constituent of cytoskeleton Cellular component • apical junction complex • cell membrane • membrane • cytoplasm • cytoskeleton Biological process • cellular protein localization • regulation of actin filament-based process • apical constriction • actomyosin structure organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	122786	319710
Ensembl	ENSG00000139926	ENSMUSG00000048285
UniProt	Q96NE9	Q8C0V9
RefSeq (mRNA)	NM_001042481 NM_001267046 NM_001267047 NM_152330	NM_028127
RefSeq (protein)	NP_001035946 NP_001253975 NP_001253976 NP_689543	NP_082403
Location (UCSC)	Chr 14: 51.49 – 51.73 Mb	Chr 12: 70.83 – 70.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000139926 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048285 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FRMD6 FERM domain containing 6".

Further reading

• Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ (2020). "Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity". Frontiers in Cellular Neuroscience. doi:10.3389/fncel.2020.552213.
• Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
• Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. PMID 21666719.
• Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828.
• Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207.
• Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.