Fucosylation

Fucosylation is the process of adding fucose sugar units to a molecule. It is a type of glycosylation.

It is important clinically,[1][2] and high levels of fucusylation have been reported in cancer.[3][4]

It is performed by fucosyltransferase enzymes.

Fucosylation has been observed in vertebrates, invertebrates, plants, bacteria, and fungi. It is known to facilitate various functions including cellular adhesion and immune regulation. Fucosylation inhibition applications are being explored for a range of clinical application including some associated with sickle cell disease, rheumatoid arthritis, tumor inhibition, and chemotherapy improvements.[5]

References
  1. Ma, B.; Simala-Grant, J. L.; Taylor, D. E. (2006). "Fucosylation in prokaryotes and eukaryotes". Glycobiology. 16 (12): 158R–184R. doi:10.1093/glycob/cwl040. PMID 16973733.
  2. Miyoshi, E.; Moriwaki, K.; Nakagawa, T. (2007). "Biological Function of Fucosylation in Cancer Biology". Journal of Biochemistry. 143 (6): 725–729. doi:10.1093/jb/mvn011. PMID 18218651.
  3. Miyoshi, Eiji (2008). Fucosylation and Cancer. Experimental Glycoscience. pp. 235–237. doi:10.1007/978-4-431-77922-3_57. ISBN 978-4-431-77921-6.
  4. Nakagawa, T.; Uozumi, N; Nakano, M; Mizuno-Horikawa, Y; Okuyama, N; Taguchi, T; Gu, J; Kondo, A; et al. (2006). "Fucosylation of N-Glycans Regulates the Secretion of Hepatic Glycoproteins into Bile Ducts". Journal of Biological Chemistry. 281 (40): 29797–29806. doi:10.1074/jbc.M605697200. PMID 16899455.
  5. Li, J., Hsu, H. C., Mountz, J. D., & Allen, J. G. (2018). Unmasking fucosylation: from cell adhesion to immune system regulation and diseases. Cell chemical biology, 25(5), 499-512.


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