GAS2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[5][6]

GAS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V5R
Identifiers
Aliases	GAS2, growth arrest specific 2, GAS-2
External IDs	OMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p14.3 Start 22,625,509 bp[1] End 22,813,055 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B4|7 32.87 cM Start 51,862,015 bp[2] End 51,994,975 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule binding • actin binding Cellular component • cytoskeleton • cytosol • actin filament • membrane • cytoplasm Biological process • cell cycle • regulation of cell shape • apoptotic process • cell cycle arrest • initiation of primordial ovarian follicle growth • antral ovarian follicle growth • regulation of Notch signaling pathway • ovulation • basement membrane organization • microtubule cytoskeleton organization • actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2620	14453
Ensembl	ENSG00000148935	ENSMUSG00000030498
UniProt	O43903	P11862
RefSeq (mRNA)	NM_001143830 NM_005256 NM_177553 NM_001351224	NM_008087 NM_001330607 NM_001330608
RefSeq (protein)	NP_001137302 NP_005247 NP_808221 NP_001338153	NP_001317536 NP_001317537 NP_032113
Location (UCSC)	Chr 11: 22.63 – 22.81 Mb	Chr 7: 51.86 – 51.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
6. "Entrez Gene: GAS2 growth arrest-specific 2".

Further reading

• Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of Oral Surgery. 33 (8): 619–21. PMID 1056466.
• Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
• Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell. 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319. S2CID 37196421.
• Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell Sci. 112 (23): 4475–82. PMID 10564664.
• Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501. PMID 11387205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486.