GCN1L1

Translational activator GCN1 is a protein that in humans is encoded by the GCN1L1 gene.[5][6]

GCN1
Identifiers
Aliases	GCN1, GCN1L, PRIC295, GCN1L1, eIF2 alpha kinase activator homolog, GCN1 activator of EIF2AK4
External IDs	OMIM: 605614 MGI: 2444248 HomoloGene: 5887 GeneCards: GCN1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 120,127,202 bp[1] End 120,194,715 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,565,254 bp[2] End 115,622,654 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribosome binding • translation factor activity, RNA binding • protein kinase binding • protein kinase regulator activity • RNA binding • cadherin binding Cellular component • polysome • ribosome • membrane • cytoplasm • cytosol Biological process • positive regulation of transcription from RNA polymerase II promoter in response to stress • positive regulation of kinase activity • cellular response to stress • cellular response to amino acid starvation • regulation of protein kinase activity • cellular response to leucine starvation • regulation of translation • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10985	231659
Ensembl	ENSG00000089154	ENSMUSG00000041638
UniProt	Q92616	E9PVA8
RefSeq (mRNA)	NM_006836	NM_172719
RefSeq (protein)	NP_006827	NP_766307
Location (UCSC)	Chr 12: 120.13 – 120.19 Mb	Chr 5: 115.57 – 115.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GCN1L1 has been shown to interact with CDC5L.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000089154 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041638 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG (August 1997). "Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2". Mol Cell Biol. 17 (8): 4474–89. doi:10.1128/mcb.17.8.4474. PMC 232301. PMID 9234705.
6. "Entrez Gene: GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)".
7. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.