GEM (gene)

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.[4][5][6]

GEM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDsOMIM: 600164 MGI: 99844 HomoloGene: 38024 GeneCards: GEM
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q22.1Start94,249,253 bp[1]
End94,262,350 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2669

14579

Ensembl

ENSG00000164949

ENSMUSG00000028214

UniProt

P55040

P55041

RefSeq (mRNA)

NM_181702
NM_005261

NM_010276

RefSeq (protein)

NP_005252
NP_859053

NP_034406

Location (UCSC)Chr 8: 94.25 – 94.26 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000164949 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. doi:10.1126/science.7912851. PMID 7912851.
  5. Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248. PMID 11956230.
  6. "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle".

Further reading


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