GNA14

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene.[5][6][7] G₁₄α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction.

GNA14
Identifiers
Aliases	GNA14, G protein subunit alpha 14
External IDs	OMIM: 604397 MGI: 95769 HomoloGene: 68386 GeneCards: GNA14
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.2 Start 77,423,079 bp[1] End 77,648,322 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 11.29 cM Start 16,435,762 bp[2] End 16,610,820 bp[2]
Gene ontology Molecular function • guanyl nucleotide binding • nucleotide binding • GTP binding • GO:0001948 protein binding • metal ion binding • G-protein coupled receptor binding • GTPase activity • signal transducer activity • G-protein beta/gamma-subunit complex binding Cellular component • cell membrane • extracellular exosome • heterotrimeric G-protein complex Biological process • platelet activation • phospholipase C-activating dopamine receptor signaling pathway • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9630	14675
Ensembl	ENSG00000156049	ENSMUSG00000024697
UniProt	O95837	P30677
RefSeq (mRNA)	NM_004297	NM_008137
RefSeq (protein)	NP_004288	NP_032163
Location (UCSC)	Chr 9: 77.42 – 77.65 Mb	Chr 19: 16.44 – 16.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Gq alpha subunit
• Heterotrimeric G protein

References

1. GRCh38: Ensembl release 89: ENSG00000156049 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024697 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
6. "Entrez Gene: GNA14 G protein subunit alpha 14 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
7. GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-14; GNA14 at OMIM. Retrieved JULY 25, 2019.