GOSR1

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.[5][6][7][8]

GOSR1
Identifiers
Aliases	GOSR1, GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDs	OMIM: 604026 MGI: 1858260 HomoloGene: 37977 GeneCards: GOSR1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,477,362 bp[1] End 30,527,592 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 76,726,602 bp[2] End 76,763,579 bp[2]
Gene ontology Molecular function • SNAP receptor activity • SNARE binding Cellular component • integral component of membrane • Golgi membrane • cis-Golgi network • Golgi apparatus • SNARE complex • membrane • Golgi medial cisterna • cytosol • transport vesicle Biological process • protein transport • ER to Golgi vesicle-mediated transport • vesicle fusion • intra-Golgi vesicle-mediated transport • retrograde transport, endosome to Golgi • regulation of vesicle targeting, to, from or within Golgi • vesicle-mediated transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9527	53334
Ensembl	ENSG00000108587	ENSMUSG00000010392
UniProt	O95249	O88630
RefSeq (mRNA)	NM_001007024 NM_001007025 NM_004871	NM_016810 NM_001356321
RefSeq (protein)	NP_001007025 NP_001007026 NP_004862	NP_058090 NP_001343250
Location (UCSC)	Chr 17: 30.48 – 30.53 Mb	Chr 11: 76.73 – 76.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[8]

Interactions

GOSR1 has been shown to interact with USO1,[9] BET1L[9][10] and STX5.[9][11][12][13]

References

1. GRCh38: Ensembl release 89: ENSG00000108587 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010392 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science. 272 (5265): 1161–3. doi:10.1126/science.272.5265.1161. PMID 8638159. S2CID 42813531.
6. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
7. Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
8. "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1".
9. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
10. Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
11. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
12. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
13. Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254. S2CID 12818072.

Further reading

• Nagahama M, Orci L, Ravazzola M, Amherdt M, Lacomis L, Tempst P, Rothman JE, Söllner TH (May 1996). "A v-SNARE implicated in intra-Golgi transport". The Journal of Cell Biology. 133 (3): 507–16. doi:10.1083/jcb.133.3.507. PMC 2120813. PMID 8636227.
• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
• Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254. S2CID 12818072.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
• Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W (Apr 1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics. 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID 10198168.
• Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". The EMBO Journal. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC 310219. PMID 10747018.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
• Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (Jun 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
• Arasaki K, Taniguchi M, Tani K, Tagaya M (Jun 2006). "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex". Molecular Biology of the Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.