GP2 (gene)

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.[5][6]

GP2
Identifiers
Aliases	GP2, ZAP75, glycoprotein 2
External IDs	OMIM: 602977 MGI: 1914383 HomoloGene: 133790 GeneCards: GP2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.3 Start 20,309,572 bp[1] End 20,327,808 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F2|7 63.88 cM Start 119,442,537 bp[2] End 119,459,285 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2813	67133
Ensembl	ENSG00000169347	ENSMUSG00000030954
UniProt	P55259	Q9D733
RefSeq (mRNA)	NM_001007240 NM_001007241 NM_001007242 NM_001502	NM_025989
RefSeq (protein)	NP_001007241 NP_001007242 NP_001007243 NP_001493	NP_080265
Location (UCSC)	Chr 16: 20.31 – 20.33 Mb	Chr 7: 119.44 – 119.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000169347 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030954 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (Jun 1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 231–2. doi:10.1159/000134730. PMID 9605860.
6. "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)".

Further reading

• Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase". Biochem. Cell Biol. 70 (10–11): 1105–14. doi:10.1139/o92-156. PMID 1284286.
• Fukuoka S, Freedman SD, Yu H, et al. (1992). "GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1189–93. doi:10.1073/pnas.89.4.1189. PMC 48414. PMID 1531535.
• Paul E, Leblond FA, LeBel D (1991). "In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor". Biochem. J. 277 (3): 879–81. doi:10.1042/bj2770879. PMC 1151326. PMID 1651706.
• Fukuoka S, Freedman SD, Scheele GA (1991). "A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2898–902. doi:10.1073/pnas.88.7.2898. PMC 51347. PMID 2011597.
• Rindler MJ, Hoops TC (1991). "The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate". Eur. J. Cell Biol. 53 (1): 154–63. PMID 2076702.
• Hoops TC, Ivanov I, Cui Z, et al. (1994). "Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells". J. Biol. Chem. 268 (34): 25694–705. PMID 7503984.
• Freedman SD, Sakamoto K, Scheele GA (1994). "Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells". Am. J. Physiol. 267 (1 Pt 1): G40–51. doi:10.1152/ajpgi.1994.267.1.G40. PMID 7519402.
• Wong SM, Lowe AW (1996). "Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas". Gene. 171 (2): 311–2. doi:10.1016/0378-1119(96)00065-0. PMID 8666297.
• Fukuoka S (2000). "Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2". Biochim. Biophys. Acta. 1491 (1–3): 376–80. doi:10.1016/S0167-4781(00)00057-9. PMID 10760606.
• Parker EM, Zaman MM, Freedman SD (2001). "GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin". Pancreas. 21 (3): 219–25. doi:10.1097/00006676-200010000-00001. PMID 11039464. S2CID 21316326.
• Kalus I, Hodel A, Koch A, et al. (2002). "Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains". Biochem. J. 362 (Pt 2): 433–42. doi:10.1042/0264-6021:3620433. PMC 1222404. PMID 11853552.
• Tsujii-Hayashi Y, Kitahara M, Yamagaki T, et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. Chem. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tamiya G, Shinya M, Imanishi T, et al. (2005). "Whole genome association study of rheumatoid arthritis using 27 039 microsatellites". Hum. Mol. Genet. 14 (16): 2305–21. doi:10.1093/hmg/ddi234. PMID 16000323.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.