GRIP2

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.[5]

GRIP2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1V62, 1X5R
Identifiers
Aliases	GRIP2, glutamate receptor interacting protein 2
External IDs	MGI: 2681173 HomoloGene: 16327 GeneCards: GRIP2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 14,489,107 bp[1] End 14,556,075 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 91,761,509 bp[2] End 91,827,250 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor signaling complex scaffold activity Cellular component • cytoplasm • cytosol • cell membrane • membrane • GO:0097483, GO:0097481 postsynaptic density • dendrite • postsynaptic membrane • glutamatergic synapse Biological process • Notch signaling pathway • positive regulation of signal transduction • artery smooth muscle contraction • protein transport • positive regulation of blood pressure • neurotransmitter receptor transport, endosome to postsynaptic membrane • vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80852	243547
Ensembl	ENSG00000144596	ENSMUSG00000030098
UniProt	Q9C0E4	n/a
RefSeq (mRNA)	NM_001080423	NM_001033353 NM_001159507
RefSeq (protein)	NP_001073892	n/a
Location (UCSC)	Chr 3: 14.49 – 14.56 Mb	Chr 6: 91.76 – 91.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GRIP2 has been shown to interact with liprin-alpha-1.[6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000144596 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030098 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GRIP2 glutamate receptor interacting protein 2".
6. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
7. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.

Further reading

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• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB (1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–91. doi:10.1016/S0896-6273(00)80568-1. PMID 9768844. S2CID 14448034.
• Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron. 21 (6): 1453–63. doi:10.1016/S0896-6273(00)80663-7. PMID 9883737. S2CID 15441813.
• Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157. S2CID 16571878.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID 11641419.
• Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling". J. Biol. Chem. 278 (6): 3590–8. doi:10.1074/jbc.M210010200. PMID 12458226.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.