GUK1

Guanylate kinase is an enzyme that in humans is encoded by the GUK1 gene.[5][6]

GUK1
Identifiers
Aliases	GUK1, GMK, guanylate kinase 1
External IDs	OMIM: 139270 MGI: 95871 HomoloGene: 665 GeneCards: GUK1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,139,962 bp[1] End 228,148,984 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,183,875 bp[2] End 59,192,212 bp[2]
Gene ontology Molecular function • ATP binding • kinase activity • nucleotide binding • transferase activity • guanylate kinase activity Cellular component • cytosol Biological process • dGMP metabolic process • purine nucleotide metabolic process • nucleobase-containing small molecule interconversion • glycoprotein transport • GMP metabolic process • ATP metabolic process • nucleotide phosphorylation • GDP biosynthetic process • dGDP biosynthetic process • dATP metabolic process • phosphorylation • GDP-mannose metabolic process • GDP metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2987	14923
Ensembl	ENSG00000143774	ENSMUSG00000020444
UniProt	Q16774 Q6IBG8	Q64520
RefSeq (mRNA)	NM_000858 NM_001159390 NM_001159391 NM_001242839 NM_001242840	NM_001159410 NM_008193
RefSeq (protein)	NP_000849 NP_001152862 NP_001152863 NP_001229768 NP_001229769 NP_000849.1 NP_001152862.1 NP_001152863.1 NP_001229768.1	NP_001152882 NP_032219
Location (UCSC)	Chr 1: 228.14 – 228.15 Mb	Chr 11: 59.18 – 59.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143774 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020444 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM (Jul 1996). "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation". FEBS Lett. 385 (3): 185–188. doi:10.1016/0014-5793(96)00365-1. PMID 8647247.
6. "Entrez Gene: GUK1 guanylate kinase 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brady WA, Kokoris MS, Fitzgibbon M, Black ME (1996). "Cloning, characterization, and modeling of mouse and human guanylate kinases". J. Biol. Chem. 271 (28): 16734–16740. doi:10.1074/jbc.271.28.16734. PMID 8663313.
• Boritzki TJ, Jackson RC, Morris HP, Weber G (1981). "Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors". Biochim. Biophys. Acta. 658 (1): 102–110. doi:10.1016/0005-2744(81)90253-9. PMID 6260205.
• Dallapiccola B, Lungarotti MS, Falorni A, et al. (1980). "Evidence for the assignment of GUK 1 gene locus to 1q32 leads to q43 segment from gene dosage effect". Ann. Genet. 23 (2): 83–85. PMID 6249178.
• Savitskiĭ IV (1990). "[Increase in 5'-nucleotidase and decrease in guanylate kinase activity in the brain and liver of irradiated rats]". Ukr. Biokhim. Zh. 62 (2): 110–114. PMID 2164269.
• Agarwal KC, Miech RP, Parks RE (1978). "Guanylate kinases from human erythrocytes, hog brain, and rat liver". Meth. Enzymol. Methods in Enzymology. 51: 483–490. doi:10.1016/S0076-6879(78)51066-5. ISBN 978-0-12-181951-4. PMID 211390.

External links

• Overview of all the structural information available in the PDB for UniProt: Q16774 (Human Guanylate kinase) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q64520 (Mouse Guanylate kinase) at the PDBe-KB.