Gaines (surname)
Gaines is a surname. Notable people with the surname include:
- Brian R. Gaines (born c. 1938), British systems scientist and engineer
- Cassie Gaines (1948–1977), American singer; backup singer for Southern rock band Lynyrd Skynyrd, and sister of fellow band member Steve Gaines (below)
- Charles Gaines (born 1942), American writer and outdoorsman
- Charles Gaines (basketball) (born 1981), American basketball player
- Chris Gaines (1999–1999), fictional alter ego of American country music singer Garth Brooks
- Chris Gaines (gridiron football) (born 1965), American football player
- Clarence Gaines (1923–2005), American basketball coach
- Corey Gaines (born 1965), American basketball player and coach
- Smokey Gaines (1940–2020), American professional basketball player
- David Gaines (racing driver) (1963-1990), American race car driver
- Edmund P. Gaines (1777–1849), United States Army officer, brother of George Strother Gaines
- Ernest J. Gaines (1933-2019), African American author
- George Gaines (set decorator) (1933–1986), American Academy Award winner for Best Art Direction
- George Strother Gaines (1784–1873), American leader in the Mississippi Territory, brother of Edmund P. Gaines
- Greg Gaines (defensive lineman) (born 1996), American NFL player
- Greg Gaines (linebacker) (born 1958), American NFL player and coach
- Jacques Gaines (fl. 1994), Canadian singer, lead singer of Soul Attorneys
- John P. Gaines (1795–1857), American Governor of Oregon Territory
- John W. Gaines (1860–1926), U.S. Congressman from Tennessee
- Lloyd L. Gaines, (born 1911, disappeared 1939), pioneering American civil rights litigant
- Max Gaines (1894–1947), American comic book publisher, father of William Gaines
- Reece Gaines (born 1981), American professional basketball player
- Richard Gaines (1904-1975), American actor
- Rowdy Gaines (born 1959), American swimmer
- Roy Gaines (born 1934), American blues guitarist
- Ruth Gaines-Shelton (1872-1934), American educator and writer
- Sheldon Gaines (born 1964), American football player
- Steve Gaines (1949–1977), American musician, guitarist and songwriter for Southern rock band Lynyrd Skynyrd
- William Gaines (1922–1992), American publisher of EC Comics, founder of Mad magazine
- William E. Gaines (1844-1912), United States Representative, Civil War veteran
- William Gaines (professor) (1933–2016), Pulitzer Prize-winning American journalist and professor of journalism
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