Gene Designer

Gene Designer is a computer software package for bioinformatics.[2][3] It is used by molecular biologists from academia, government, and the pharmaceutical, chemical, agricultural, and biotechnology industries to design,[4] clone, and validate genetic sequences. It is proprietary software, released as freeware needing registration.

Gene Designer
Gene Designer Sequence View enables manipulation of sequence elements, codon choices, and oligonucleotide positions. Rapidly search for sequence motifs, restriction sites, and open reading frames.
Developer(s)DNA2.0[1]
Initial release2006 (2006)
Stable release
2.01.191 / October 9, 2015 (2015-10-09)
Operating systemWindows, macOS, Linux
Platformx86, x86-64
Available inEnglish
TypeMolecular biology toolkit
LicenseFreeware, registration required
Websitewww.dna20.com/resources/genedesigner

Features

Gene Designer enables molecular biologists to manage the full gene design process in one application, using a range of design tools.

Gene Designer clones with a drag and drop feature. Users can drag a vector and insert into the Cloning Tool; cut, combine and clone. Gene Designer assembles a clone that can then be dropped directly into a project.

Educator and student use

This free software has been incorporated into classroom and lab curricula for synthetic biology, systems biology, bioengineering, and bioinformatics. Students create and complete projects which manage the full gene design process in one application, using a range of design tools.

Examples of use in curricula:

  • Synthetic Biophotonics Course; Utah State University, College of Engineering[5]
  • Lab Project using Gene Designer 2.0[6]
  • Systems Biology Lesson Overview[7]
  • Synthetic Biology Lesson Overview[8]
  • Student Projects[9]

See also

References
  1. DNA2.0
  2. Villalobos, Alan; Ness, Jon E; Gustafsson, Claes; Minshull, Jeremy; Govindarajan, Sridhar (2006). "Gene Designer: A synthetic biology tool for constructing artificial DNA segments". BMC Bioinformatics. 7: 285. doi:10.1186/1471-2105-7-285. PMC 1523223. PMID 16756672.
  3. Villalobos, Alan; Welch, Mark; Minshull, Jeremy (2012). "In Silico Design of Functional DNA Constructs". In Peccoud, Jean (ed.). Gene Synthesis: Methods and Protocols. Methods in Molecular Biology. 852. pp. 197–213. doi:10.1007/978-1-61779-564-0_15. ISBN 978-1-61779-563-3. PMID 22328435.
  4. Welch, M; Villalobos, A; Gustafsson, C; Minshull, J (2011). "Designing genes for successful protein expression". In Voigt, Christopher (ed.). Synthetic Biology, Part B: Computer Aided Design and DNA Assembly. Methods in Enzymology. 498. pp. 43–66. doi:10.1016/B978-0-12-385120-8.00003-6. ISBN 9780123851208. PMID 21601673.
  5. http://www.engr.usu.edu/wiki/index.php/Synthetic_Biophotonics_2010%5B%5D
  6. http://www.engr.usu.edu/wiki/index.php/Synthetic_Biophotonics_2010_Systems_Biology_Laboratory%5B%5D
  7. http://www.engr.usu.edu/wiki/index.php/Synthetic_Biophotonics_2010_Systems_Biology%5B%5D
  8. http://www.engr.usu.edu/wiki/index.php/Synthetic_Biophotonics_2010_Synthetic_Biology%5B%5D
  9. http://www.engr.usu.edu/wiki/index.php/Synthetic_Biophotonics_2010_Student_Projects%5B%5D
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