Geranylgeranyl diphosphate reductase
Geranylgeranyl diphosphate reductase (EC 1.3.1.83, geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP+ oxidoreductase.[1][2][3] This enzyme catalises the following chemical reaction
- phytyl diphosphate + 3 NADP+ geranylgeranyl diphosphate + 3 NADPH + 3 H+
| Geranylgeranyl diphosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.83 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme also acts on geranylgeranyl-chlorophyll a.
References
- Soll J, Schultz G, Rüdiger W, Benz J (April 1983). "Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts". Plant Physiology. 71 (4): 849–54. doi:10.1104/pp.71.4.849. PMC 1066133. PMID 16662918.
- Tanaka R, Oster U, Kruse E, Rudiger W, Grimm B (July 1999). "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase". Plant Physiology. 120 (3): 695–704. doi:10.1104/pp.120.3.695. PMC 59307. PMID 10398704.
- Keller Y, Bouvier F, d'Harlingue A, Camara B (January 1998). "Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase". European Journal of Biochemistry. 251 (1–2): 413–7. doi:10.1046/j.1432-1327.1998.2510413.x. PMID 9492312.
External links
- Geranylgeranyl+diphosphate+reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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