Gerhard A. Holzapfel

Gerhard Alfred Holzapfel (born May 22, 1961) is an Austrian scientist, (bio)mechanician. He is currently a Professor of Biomechanics and Head of the Institute of Biomechanics at Graz University of Technology, Austria, since 2007.[1][2] He is also the International Chair of Biomechanics (adjunct professorship) at the Norwegian University of Science and Technology (NTNU),[3] and a visiting professor at the School of Mathematics and Statistics, University of Glasgow, Scotland.[4] He was a Professor of Biomechanics at KTH Royal Institute of Technology in Stockholm, Sweden, for 9 years (7 years as an adjunct professor) until 2013. He is the co-founder and co-editor-in-chief of the international scientific journal Biomechanics and Modeling in Mechanobiology by Springer Nature since the first issue published in June 2002.[5]

Gerhard A. Holzapfel
BornMay 22, 1961
Graz, Styria, Austria
NationalityAustrian
Alma materGraz University of Technology (PhD)
Known forConstitutive and computational modeling of fiber-reinforced materials, soft biological tissues including blood vessels in health and disease
Awards
Scientific career
FieldsNonlinear Solid Mechanics, Biomechanics, Mechanobiology
Institutions

Holzapfel is widely known for his contributions to the fields of nonlinear solid mechanics, constitutive and computational modeling of fiber-reinforced materials and soft biological tissues including blood vessels in health and disease. He has been listed as a Highly Cited Researcher in Engineering selected by ISI Web of Science, Thomson Reuters and listed as "The World's Most Influential Scientific Minds: 2014".[6] His graduate textbook, Nonlinear Solid Mechanics: A Continuum Approach for Engineering[7] published in 2000, has become a standard reference in the area of solid mechanics.

Education and training

Gerhard A. Holzapfel received his M.S. degree in Civil Engineering and his Ph.D. in Mechanical Engineering from Graz University of Technology in 1985 and 1990, respectively. In 1991, he traveled to Shenyang in the Northeast of P.R. China to work as a visiting scholar at an institution currently part of the Shenyang University. Then, he received a Schrödinger Scholarship from the Austrian Science Fund (Wissenschaftsfonds FWF) to work as a Post-Doctoral Fellow at the Division of Applied Mechanics, Department of Mechanical Engineering, Stanford University, CA, USA, with the late Professor Juan C. Simo from 1993 to 1995.[8] He received his Habilitation in Mechanics from the Vienna University of Technology, Austria, in 1996. From May 1987 to November 2004, he was an Assistant at the Institute of Strength of Materials and then an Associate Professor at the Institute of Structural Analysis, Graz University of Technology, Austria.

Research

Holzapfel's research has mainly focused on nonlinear continuum mechanics, multi-scale constitutive modeling of solids at finite strains including fiber reinforcement, computational methods, fracture, and material failure. He has made seminal contributions to biomechanics, embracing experiments, continuum mechanics modeling and finite element implementations for a variety of soft biological tissues including artery walls, heart tissue, and brain tissues.

In recent years, he has increasingly directed his attention towards the biomechanics and mechanobiology of soft biological tissues, the cardiovascular system including blood vessels in health and diseases such as aneurysm and aortic dissection, therapeutic interventions such as balloon angioplasty and stent implantation.

He has also made contributions in experimental biomechanics addressing phenomena at the nano, micro, or macrolevels. He used polarized light microscopy, second-harmonic imaging, and two-photon excitation microscopy together with medical image processing to visualize the nanostructure of soft tissues.

Besides his well-known textbook Nonlinear Solid Mechanics: A Continuum Approach for Engineering,[7] two of the constitutive models proposed by his group and longtime collaborator Ray Ogden are now referred to as the hgo [9] and goh [10] models which have been implemented in commercial software such as Simulia Abaqus[11]

Awards and honors

Holzapfel has received many awards and honors including the following:

Selected publications

Holzapfel has authored a graduate textbook and co-edited seven books. He contributed chapters to 20+ other books, and published 220+ peer-reviewed journal articles. Some of his most influential publications include:

  • GA Holzapfel (2000), Nonlinear Solid Mechanics. A Continuum Approach for Engineering. John Wiley & Sons, Chichester, 2000. ISBN 978-0-471-82319-3
  • GA Holzapfel, TC Gasser, RW Ogden (2000), A new constitutive framework for arterial wall mechanics and a comparative study of material models. Journal of Elasticity and the Physical Science of Solids 61 (1-3), 1-48. DOI: 10.1023/A:1010835316564
  • GA Holzapfel, G Sommer, CT Gasser, P Regitnig (2005), Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling. American Journal of Physiology. Heart and Circulatory Physiology 289 (5), H2048-2058. DOI: 10.1152/ajpheart.00934.2004
  • TC Gasser, RW Ogden, GA Holzapfel (2006), Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. Journal of the Royal Society Interface 3 (6), 15-35. DOI: 10.1098/rsif.2005.0073
  • GA Holzapfel, RW Ogden (2009), Constitutive modelling of passive myocardium: a structurally based framework for material characterization. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 367 (1902), 3445-3475. DOI: 10.1098/rsta.2009.0091
  • JD Humphrey, GA Holzapfel (2012), Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms. Journal of Biomechanics 45 (5), 805-814. DOI: 10.1016/j.jbiomech.2011.11.021
  • AJ Schriefl, G Zeindlinger, DM Pierce, P Regitnig, GA Holzapfel (2012), Determination of the layer-specific distributed collagen fibre orientations in human thoracic and abdominal aortas and common iliac arteries. Journal of the Royal Society Interface 9 (71), 1275-1286. DOI: 10.1098/rsif.2011.0727
  • GA Holzapfel, JA Niestrawska, RW Ogden, AJ Reinisch, AJ Schriefl (2015), Modelling non-symmetric collagen fibre dispersion in arterial walls. Journal of the Royal Society Interface 12 (106), 20150188. DOI: 10.1098/rsif.2015.0188
  • JA Niestrawska, C Viertler, P Regitnig, TU Cohnert, G Sommer, GA Holzapfel (2016), Microstructure and mechanics of healthy and aneurysmatic abdominal aortas: experimental analysis and modelling. Journal of the Royal Society Interface 13 (124), 20160620. DOI: 10.1098/rsif.2016.0620
  • S Budday, G Sommer, C Birkl, C Langkammer, J Haybaeck, J Kohnert, M Bauer, F Paulsen, P Steinmann, E Kuhl, GA Holzapfel (2017), Mechanical characterization of human brain tissue. Acta Biomaterialia 48, 319-340. DOI: 10.1016/j.actbio.2016.10.036
  • K Li, RW Ogden, GA Holzapfel (2018), A discrete fibre dispersion method for excluding fibres under compression in the modelling of fibrous tissues. Journal of the Royal Society Interface 15 (138), 20170766. DOI: 10.1098/rsif.2017.0766
  • GA Holzapfel, RW Ogden, S Sherifova (2019), On fibre dispersion modelling of soft biological tissues: a review. Proceedings of the Royal Society A 475 (2224), 20180736. DOI: 10.1098/rspa.2018.0736
  • O Gültekin, SP Hager, H Dal, GA Holzapfel (2019), Computational modeling of progressive damage and rupture in fibrous biological tissues: application to aortic dissection. Biomechanics and Modeling in Mechanobiology 18 (6), 1607-1628. DOI: 10.1007/s10237-019-01164-y

References
  1. "Institute of Biomechanics Website". Retrieved 7 January 2021.
  2. "List of Institute Heads at TU Graz in December 2007". Retrieved 7 January 2021.
  3. "Holzapfel profile at Norwegian University of Science and Technology". Retrieved 26 December 2020.
  4. "Holzapfel profile at University of Glasgow". Retrieved 7 January 2021.
  5. "Biomechanics and Modeling in Mechanobiology website". Springer Nature. Retrieved 7 January 2021.
  6. "The World's Most Influential Scientific Minds 2014. Thomson Reuters has launched "Highly Cited Researchers", a compilation of influential names in science". Thomson Reuters. Retrieved 7 January 2021.
  7. "Nonlinear Solid Mechanics". John Wiley & Sons, Inc. Retrieved 7 January 2021.
  8. "Austrian Science Fund (Der Wissenschaftsfonds FWF) Webpage on the Schröderinger Scholarship Award for Gerhard A. Holzapfel". Retrieved 7 January 2021.
  9. Holzapfel, Gerhard A.; Gasser, Thomas C.; Ogden, Ray W. (2000). "A new constitutive framework for arterial wall mechanics and a comparative study of material models". Journal of Elasticity and the Physical Science of Solids. 61 (1–3): 1–48. doi:10.1023/A:1010835316564. S2CID 9214560. Retrieved 26 December 2020.
  10. Gasser, Thomas C.; Ogden, Ray W.; Holzapfel, Gerhard A. (2006). "Hyperelastic modelling of arterial layers with distributed collagen fibre orientations". Journal of the Royal Society Interface. 3 (6): 15–35. doi:10.1098/rsif.2005.0073. PMC 1618483. PMID 16849214. Retrieved 26 December 2020.
  11. "Abaqus documentation on hyperelastic models". Dassault Systèmes Simulia Corp. Retrieved 7 January 2021.
  12. "Austrian Science Fund (Der Wissenschaftsfonds FWF) Webpage on the Austrian Start-Prize Award for Gerhard A. Holzapfel". Retrieved 7 January 2021.
  13. "Austrian Academy of Sciences Webpage on the Erwin Schrödinger Award for Holzapfel". Retrieved 7 January 2021.
  14. "Erwin Schrödinger-Preis 2011 an Biomechaniker Holzapfel". Retrieved 7 January 2021.
  15. "European Alliance for Medical and Biological Engineering & Science Fellow Webpage". Retrieved 26 January 2021.
  16. "Austrian Academy of Sciences Webpage". Retrieved 26 January 2021.
  17. "Academia Europaea Webpage". Retrieved 26 January 2021.
  18. "Euromech fellows". European Mechanics Society. Retrieved 7 January 2021.
  19. "World Council on Biomechanics Website". Retrieved 7 January 2021.
  20. "EASA Website".
  21. "William Prager Medal". socengsci.org. Retrieved 7 January 2021.
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