Giantin

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene.[5][6][7] Giantin is a disulfide-linked homodimer.

GOLGB1
Identifiers
Aliases	GOLGB1, GCP, GCP372, GOLIM1, golgin B1
External IDs	OMIM: 602500 MGI: 1099447 HomoloGene: 68401 GeneCards: GOLGB1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 121,663,199 bp[1] End 121,749,767 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 36,875,140 bp[2] End 36,933,085 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA binding Cellular component • integral component of membrane • Golgi membrane • Golgi stack • cis-Golgi network • Golgi apparatus • membrane • endoplasmic reticulum-Golgi intermediate compartment Biological process • ER to Golgi vesicle-mediated transport • Golgi organization • regulation of transcription, DNA-templated • protein localization to pericentriolar material Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2804	224139
Ensembl	ENSG00000173230	ENSMUSG00000034243
UniProt	Q14789	n/a
RefSeq (mRNA)	NM_001256486 NM_001256487 NM_001256488 NM_004487 NM_001366282 NM_001366283 NM_001366284	NM_030035
RefSeq (protein)	NP_001243415 NP_001243416 NP_001243417 NP_004478 NP_001353211 NP_001353212 NP_001353213	n/a
Location (UCSC)	Chr 3: 121.66 – 121.75 Mb	Chr 16: 36.88 – 36.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GOLGB1 has been shown to interact with ACBD3 and with PLK3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000173230 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034243 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Linstedt AD, Hauri HP (Nov 1993). "Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa". Mol Biol Cell. 4 (7): 679–93. doi:10.1091/mbc.4.7.679. PMC 300978. PMID 7691276.
6. Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
7. "Entrez Gene: GOLGB1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1".
8. Sohda, M; Misumi Y; Yamamoto A; Yano A; Nakamura N; Ikehara Y (Nov 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. ISSN 0021-9258. PMID 11590181.

Further reading

• Sohda M, Misumi Y, Fujiwara T, et al. (1995). "Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex". Biochem. Biophys. Res. Commun. 205 (2): 1399–408. doi:10.1006/bbrc.1994.2821. PMID 7802676.
• Seelig HP, Schranz P, Schröter H, et al. (1994). "Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections". J. Autoimmun. 7 (1): 67–91. doi:10.1006/jaut.1994.1006. PMID 8198703.
• Sönnichsen B, Lowe M, Levine T, et al. (1998). "A role for giantin in docking COPI vesicles to Golgi membranes". J. Cell Biol. 140 (5): 1013–21. doi:10.1083/jcb.140.5.1013. PMC 2132694. PMID 9490716.
• Linstedt AD, Jesch SA, Mehta A, et al. (2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus". J. Biol. Chem. 275 (14): 10196–201. doi:10.1074/jbc.275.14.10196. PMID 10744704.
• Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments". J. Cell Biol. 150 (3): 475–88. doi:10.1083/jcb.150.3.475. PMC 2175190. PMID 10931861.
• Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic". J. Biol. Chem. 276 (4): 2693–700. doi:10.1074/jbc.M007957200. PMID 11035033.
• Sohda M, Misumi Y, Yamamoto A, et al. (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.
• Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
• Gillingham AK, Pfeifer AC, Munro S (2003). "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin". Mol. Biol. Cell. 13 (11): 3761–74. doi:10.1091/mbc.E02-06-0349. PMC 133590. PMID 12429822.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles". Science. 307 (5712): 1095–8. doi:10.1126/science.1108061. PMID 15718469. S2CID 12601850.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rosing M, Ossendorf E, Rak A, Barnekow A (2007). "Giantin interacts with both the small GTPase Rab6 and Rab1". Exp. Cell Res. 313 (11): 2318–25. doi:10.1016/j.yexcr.2007.03.031. PMID 17475246.