Guanosine deaminase
In enzymology, a guanosine deaminase (EC 3.5.4.15) is an enzyme that catalyzes the chemical reaction
- guanosine + H2O xanthosine + NH3
| guanosine deaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.4.15 | ||||||||
| CAS number | 9067-85-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are guanosine and H2O, whereas its two products are xanthosine and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is guanosine aminohydrolase. This enzyme is also called guanosine aminase.
References
- Isihida Y, Shirafiji H, Kida M, Yoneda M (1969). "Studies on the guanosine degrading system in bacterial cell. III Preparation and properties of guanosine deaminase". Agric. Biol. Chem. 33: 384–390. doi:10.1080/00021369.1969.10859324.
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