HOMER2

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.[5][6][7]

HOMER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7A
Identifiers
Aliases	HOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDs	OMIM: 604799 MGI: 1347354 HomoloGene: 3560 GeneCards: HOMER2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.2 Start 82,836,946 bp[1] End 82,986,153 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 81,600,481 bp[2] End 81,707,527 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein homodimerization activity • protein domain specific binding • GKAP/Homer scaffold activity • actin binding • G-protein coupled glutamate receptor binding • glutamate receptor binding • protein heterodimerization activity Cellular component • cytoplasm • neuronal cell body • postsynaptic membrane • dendrite • synapse • GO:0097483, GO:0097481 postsynaptic density • membrane • apical part of cell • stereocilium tip • cell projection • stereocilium • cell membrane • cell junction • cytosol • glutamatergic synapse • neuron projection Biological process • G-protein coupled glutamate receptor signaling pathway • chemical homeostasis within a tissue • behavioral response to cocaine • regulation of G-protein coupled receptor protein signaling pathway • sensory perception of sound • calcium-mediated signaling using intracellular calcium source • negative regulation of interleukin-2 production • negative regulation of calcineurin-NFAT signaling cascade • regulation of store-operated calcium entry • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9455	26557
Ensembl	ENSG00000103942	ENSMUSG00000025813
UniProt	Q9NSB8	Q9QWW1
RefSeq (mRNA)	NM_004839 NM_199330 NM_199331 NM_199332	NM_001164086 NM_001164087 NM_011983 NM_177029
RefSeq (protein)	NP_004830 NP_955362	NP_001157558 NP_001157559 NP_036113
Location (UCSC)	Chr 15: 82.84 – 82.99 Mb	Chr 7: 81.6 – 81.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.[7]

Interactions

HOMER2 has been shown to interact with RYR1.[8]

See also

• HOMER1
• HOMER3

References

1. GRCh38: Ensembl release 89: ENSG00000103942 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025813 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
6. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
7. "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
8. Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. United States. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Further reading

• Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
• Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
• Kim JT, Park SH, Kim SK, et al. (2003). "Potential role of Homer-2a on cutaneous vascular anomaly". J. Korean Med. Sci. 17 (5): 636–40. PMC 3054924. PMID 12378015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons". Mol. Cell. Neurosci. 22 (2): 188–201. doi:10.1016/S1044-7431(03)00037-X. PMID 12676529.
• Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ishibashi T, Ogawa S, Hashiguchi Y, et al. (2005). "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems". J. Biochem. 137 (5): 617–23. doi:10.1093/jb/mvi074. PMID 15944415.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Dahl JP, Kampman KM, Oslin DW, et al. (2006). "Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population". Psychiatr. Genet. 15 (4): 277–83. doi:10.1097/00041444-200512000-00010. PMID 16314758.