HOOK2

Protein Hook homolog 2 (HK2) is a protein[5] that in humans is encoded by the HOOK2 gene.[6][7]

HOOK2
Identifiers
Aliases	HOOK2, HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDs	OMIM: 607824 MGI: 2181664 HomoloGene: 8332 GeneCards: HOOK2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,763,003 bp[1] End 12,872,740 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 84,990,603 bp[2] End 85,003,349 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding • microtubule binding • dynein light intermediate chain binding Cellular component • HOPS complex • cytoplasm • microtubule organizing center • centrosome • microtubules • cytoskeleton • FHF complex • cytosol • intracellular membrane-bounded organelle Biological process • protein transport • lysosome organization • early endosome to late endosome transport • endocytosis • endosome organization • endosome to lysosome transport • cytoskeleton-dependent intracellular transport • cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29911	170833
Ensembl	ENSG00000095066	ENSMUSG00000052566
UniProt	Q96ED9	Q7TMK6
RefSeq (mRNA)	NM_001100176 NM_013312	NM_001167991 NM_133255 NM_001363497 NM_001363498
RefSeq (protein)	NP_001093646 NP_037444	NP_001161463 NP_573518 NP_001350426 NP_001350427 NP_001359286 NP_001359287 NP_001359288 NP_001359289 NP_001359290 NP_001359291
Location (UCSC)	Chr 19: 12.76 – 12.87 Mb	Chr 8: 84.99 – 85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000095066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052566 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. PMC 1460498. PMID 9927460.
6. Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
7. "Entrez Gene: hook homolog 2 (Drosophila)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex". Mol. Biol. Cell. 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC 2592673. PMID 18799622.
• Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome". Mol. Biol. Cell. 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC 2777108. PMID 19793914.
• Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156. PMID 17540036.
• Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function". Traffic. 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.