HOOK3

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.[5][6]

HOOK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J8E
Identifiers
Aliases	HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs	OMIM: 607825 MGI: 2443554 HomoloGene: 13022 GeneCards: HOOK3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,896,946 bp[1] End 43,030,535 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 26,021,421 bp[2] End 26,119,224 bp[2]
Gene ontology Molecular function • microtubule binding • GO:0001948 protein binding • identical protein binding • dynein light intermediate chain binding • dynactin binding • dynein light chain binding • dynein intermediate chain binding Cellular component • HOPS complex • FHF complex • cis-Golgi network • centriolar satellite • microtubules • cytoskeleton • cytosol • pericentriolar material • cytoplasm • Golgi apparatus • centrosome Biological process • endosome to lysosome transport • endosome organization • neuronal stem cell population maintenance • Golgi localization • early endosome to late endosome transport • cytoplasmic microtubule organization • protein transport • lysosome organization • microtubule anchoring at centrosome • interkinetic nuclear migration • negative regulation of neurogenesis • protein localization to centrosome • cytoskeleton-dependent intracellular transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84376	320191
Ensembl	ENSG00000168172	ENSMUSG00000037234
UniProt	Q86VS8	Q8BUK6
RefSeq (mRNA)	NM_032410	NM_207659
RefSeq (protein)	NP_115786	NP_997542
Location (UCSC)	Chr 8: 42.9 – 43.03 Mb	Chr 8: 26.02 – 26.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000168172 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037234 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. PMC 1460498. PMID 9927460.
6. "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

Further reading

• Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking". Mol. Microbiol. 49 (6): 1565–76. doi:10.1046/j.1365-2958.2003.03668.x. PMID 12950921. S2CID 30972454.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3". J. Cell Sci. 117 (Pt 9): 1747–56. doi:10.1242/jcs.01039. PMID 15075236.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A." J. Biol. Chem. 282 (11): 7973–81. doi:10.1074/jbc.M611537200. PMID 17237231.
• Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma". Endocr. Relat. Cancer. 14 (2): 445–52. doi:10.1677/ERC-07-0039. PMID 17639057.