HRC (gene)

Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene.[3][4]

HRC
Identifiers
Aliases	HRC, histidine rich calcium binding protein
External IDs	OMIM: 142705 HomoloGene: 135866 GeneCards: HRC
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,151,198 bp[1] End 49,155,396 bp[1]
Gene ontology Molecular function • ATPase binding • ion channel binding • GO:0001948 protein binding • calcium ion binding Cellular component • sarcoplasmic reticulum lumen • sarcoplasmic reticulum • Z disc • sarcoplasmic reticulum membrane • endoplasmic reticulum lumen Biological process • muscle contraction • regulation of ryanodine-sensitive calcium-release channel activity • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • positive regulation of relaxation of cardiac muscle • regulation of heart rate • regulation of calcium ion transmembrane transport • positive regulation of heart rate • calcium ion homeostasis • regulation of peptidyl-serine phosphorylation • regulation of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of cytosolic calcium ion concentration • positive regulation of heart contraction • regulation of cell communication by electrical coupling involved in cardiac conduction • post-translational modification • cellular protein metabolic process • negative regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3270	n/a
Ensembl	ENSG00000130528	n/a
UniProt	P23327	n/a
RefSeq (mRNA)	NM_002152	n/a
RefSeq (protein)	NP_002143	n/a
Location (UCSC)	Chr 19: 49.15 – 49.16 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity[4]

References

1. GRCh38: Ensembl release 89: ENSG00000130528 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics. 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
4. "Entrez Gene: HRC histidine rich calcium binding protein".

Further reading

• Anderson NL, Anderson NG (Nov 2002). "The human plasma proteome: history, character, and diagnostic prospects". Molecular & Cellular Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
• Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL (May 1989). "Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins". The Journal of Biological Chemistry. 264 (14): 8260–70. PMID 2498310.
• Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS (Aug 1999). "Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein". FEBS Letters. 456 (3): 399–402. doi:10.1016/S0014-5793(99)00993-X. PMID 10462052. S2CID 19920072.
• Lee HG, Kang H, Kim DH, Park WJ (Oct 2001). "Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum". The Journal of Biological Chemistry. 276 (43): 39533–8. doi:10.1074/jbc.M010664200. PMID 11504710.
• Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A (Dec 2001). "Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region". Biochemical and Biophysical Research Communications. 289 (5): 1125–34. doi:10.1006/bbrc.2001.6126. PMID 11741309.
• Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ (Jan 2003). "Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein)". Biochemical and Biophysical Research Communications. 300 (1): 192–6. doi:10.1016/S0006-291X(02)02829-2. PMID 12480542.
• Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL (May 2004). "HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo". Molecular and Cellular Biology. 24 (9): 3757–68. doi:10.1128/MCB.24.9.3757-3768.2004. PMC 387749. PMID 15082771.
• Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (Oct 2004). "Regulation of myocardial function by histidine-rich, calcium-binding protein". American Journal of Physiology. Heart and Circulatory Physiology. 287 (4): H1705–11. doi:10.1152/ajpheart.01211.2003. PMID 15191886. S2CID 15011211.
• Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG (Sep 2007). "Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase". American Journal of Physiology. Heart and Circulatory Physiology. 293 (3): H1581–9. doi:10.1152/ajpheart.00278.2007. PMID 17526652.
• Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG (2013). "Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein". Journal of the American Heart Association. 2 (5): e000460. doi:10.1161/JAHA.113.000460. PMC 3835262. PMID 24125847.