HSPBP1

Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.[5][6][7]

HSPBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XQR, 1XQS
Identifiers
Aliases	HSPBP1, FES1, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA (Hsp70) binding protein 1
External IDs	OMIM: 612939 MGI: 1913495 HomoloGene: 40827 GeneCards: HSPBP1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,262,223 bp[1] End 55,280,381 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,660,521 bp[2] End 4,685,068 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0048551 enzyme inhibitor activity • GO:0001948 protein binding • adenyl-nucleotide exchange factor activity • ubiquitin protein ligase binding Cellular component • cytoplasm • endoplasmic reticulum Biological process • positive regulation of protein ubiquitination • protein folding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0048553 negative regulation of catalytic activity • GO:0048552 regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23640	66245
Ensembl	ENSG00000133265	ENSMUSG00000063802
UniProt	Q9NZL4	Q99P31
RefSeq (mRNA)	NM_001130106 NM_001297600 NM_012267	NM_024172 NM_001360629
RefSeq (protein)	NP_001123578 NP_001284529 NP_036399	NP_077134 NP_001347558
Location (UCSC)	Chr 19: 55.26 – 55.28 Mb	Chr 7: 4.66 – 4.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HSPBP1 has been shown to interact with HSPA8[8][9] and HSPA4.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000133265 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063802 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Raynes DA, Guerriero V (Jan 2000). "Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (1–2): 203–7. doi:10.1016/s0167-4781(99)00238-9. PMID 10786638.
6. Raynes DA, Guerriero V (Dec 1998). "Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein". The Journal of Biological Chemistry. 273 (49): 32883–8. doi:10.1074/jbc.273.49.32883. PMID 9830037.
7. "Entrez Gene: HSPBP1 hsp70-interacting protein".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
10. Oh WK, Song J (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Molecules and Cells. 16 (1): 84–91. PMID 14503850.

Further reading

• Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (Aug 1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4): 471–80. doi:10.1016/S0092-8674(00)81588-3. PMID 9727490. S2CID 9234420.
• Kabani M, McLellan C, Raynes DA, Guerriero V, Brodsky JL (Nov 2002). "HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor". FEBS Letters. 531 (2): 339–42. doi:10.1016/S0014-5793(02)03570-6. PMID 12417338. S2CID 46738074.
• McLellan CA, Raynes DA, Guerriero V (May 2003). "HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain". The Journal of Biological Chemistry. 278 (21): 19017–22. doi:10.1074/jbc.M301109200. PMID 12651857.
• Oh WK, Song J (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Molecules and Cells. 16 (1): 84–91. PMID 14503850.
• Lu QF, Bai M, Zhang HJ, Li JC, Xiao CF, Chen S, Wu TC (Oct 2003). "[Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]". Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases. 21 (5): 359–61. PMID 14761400.
• Alberti S, Böhse K, Arndt V, Schmitz A, Höhfeld J (Sep 2004). "The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator". Molecular Biology of the Cell. 15 (9): 4003–10. doi:10.1091/mbc.E04-04-0293. PMC 515335. PMID 15215316.
• Shomura Y, Dragovic Z, Chang HC, Tzvetkov N, Young JC, Brodsky JL, Guerriero V, Hartl FU, Bracher A (Feb 2005). "Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange". Molecular Cell. 17 (3): 367–79. doi:10.1016/j.molcel.2004.12.023. PMID 15694338.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C (Nov 2005). "Regulation of the cytoplasmic quality control protein degradation pathway by BAG2". The Journal of Biological Chemistry. 280 (46): 38673–81. doi:10.1074/jbc.M507986200. PMID 16169850.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gottwald E, Herschbach M, Lahni B, Miesfeld RL, Kunz S, Raynes DA, Guerriero V (Jun 2006). "Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression". Cell Biology International. 30 (6): 553–8. doi:10.1016/j.cellbi.2006.03.005. PMID 16677834. S2CID 2046710.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Bivik C, Rosdahl I, Ollinger K (Mar 2007). "Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes". Carcinogenesis. 28 (3): 537–44. doi:10.1093/carcin/bgl152. PMID 16950797.
• Swayne LA, Braun JE (Mar 2007). "Aggregate-centered redistribution of proteins by mutant huntingtin". Biochemical and Biophysical Research Communications. 354 (1): 39–44. doi:10.1016/j.bbrc.2006.12.129. PMID 17208201.