HULC (gene)

In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver.[2][3] It may have a role in the post-transcriptional regulation of gene expression.[2] It downregulates the expression of several microRNAs, including miR-372.[4] Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.[4]

HULC
Identifiers
Aliases	HULC, HCCAT1, LINC00078, NCRNA00078, hepatocellular carcinoma up-regulated long non-coding RNA
External IDs	OMIM: 612210 GeneCards: HULC
Orthologs
Species	Human	Mouse
Entrez	728655	n/a
Ensembl	ENSG00000251164 ENSG00000276019	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata
View/Edit Human

See also

• Long noncoding RNA

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M, Zatloukal K (Jan 2007). "Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA". Gastroenterology. 132 (1): 330–342. doi:10.1053/j.gastro.2006.08.026. PMID 17241883.
3. Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H, Akkawi M (Jun 2009). "Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis". European Journal of Gastroenterology & Hepatology. 21 (6): 688–692. doi:10.1097/meg.0b013e328306a3a2. PMID 19445043. S2CID 39245106.
4. Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y, Chen N, Sun F, Fan Q (Sep 2010). "CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer". Nucleic Acids Research. 38 (16): 5366–5383. doi:10.1093/nar/gkq285. PMC 2938198. PMID 20423907.

Further reading

• Li D, Song YM, Zhan QM (Nov 2010). "[Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3]". Zhonghua Yi Xue Za Zhi. 90 (44): 3156–3159. PMID 21211351.