Harold Leeming Sheehan

Harold Leeming Sheehan FRCP FRCOG FRCPath TD (1900–1988) was a British physician, pathologist, and professor of pathology.[3][4]

Harold Leeming Sheehan
Born(1900-08-04)4 August 1900
Carlisle, Cumberland
Died25 October 1988(1988-10-25) (aged 88)
OccupationPhysician and professor of pathology
Known forSheehan's syndrome[1][2]

Biography

Harold Sheehan, whose father was a general practitioner, was the second of thirteen children (6 males and 7 females). After education at Carlisle Grammar School, Harold Sheehan studied medicine at the University of Manchester, graduating MB ChB in 1921. Harold Sheehan began his practice of medicine by joining his elder brother Gerald, who had taken over their father's practice upon the latter's death. Harold Sheehan worked as a general practitioner from 1921 to 1927.[3]

He became in 1927 a demonstrator, and later a lecturer, in the University of Manchester's department of pathology.[3] There the professor of pathology was John Shaw Dunn,[5] who supervised Sheehan's MD thesis (1931) on the deposition of dyes in the mammalian kidney. In 1932 Sheehan graduated MSc with a thesis on renal elimination of injected urea and creatine. By means of a Rockefeller medical fellowship for the academic year 1934–1935, he studied renal function at the Johns Hopkins Medical School's department of pathology.[3]

In 1935 he was appointed director of research at the Glasgow Royal Maternity Hospital and lecturer on pathology.[4] In the years preceding WWII he became an internationally recognised expert on diseases of pregnancy.[3]

He analysed the effects of obstetrical shock, he differentiated between the fatty liver of delayed chloroform poisoning and the condition of primary fatty liver of pregnancy, he demonstrated the reactivation of latent rheumatic heart disease that was induced by pregnancy, he clarified the effects of eclampsia upon the liver and kidneys, he identified the encephalopathy of hyperemesis gravidarum as Wernicke's disease, he recognized the association between concealed accidental haemorrhage and renal cortical necrosis and recognized that obstetrical shock and haemorrhage could induce necrosis of the anterior lobe of the pituitary gland.[3]

He joined the Territorial Army in 1939 and became deputy director of pathology at the allied forces' headquarters in Italy.[4] He was mentioned in dispatches and attained the rank of colonel in the RAMC.[3]

... he helped to show that the sporadic jaundice seen in soldiers treated with intravenous arsenicals was caused by dirty syringes and needles infected with what we now know as hepatitis B virus.[4]

He gained a DSc in 1940 and qualified MRCP in 1941. He was appointed in 1946 to the University of Liverpool's chair of pathology and built up a prestigious department. He acted as a histopathological consultant for the region surrounding Merseyside and monitored obstetrical deaths in the region, promptly performing many autopsies himself.[3]

In 1949, with Victor Kirwan Summers[6] he published an important paper on the syndrome of hypopituitarism.[3]

The paper showed convincingly that emaciation and premature senility, previously considered to be essential for the diagnosis of pituitary insufficiency, were not features of the syndrome. This paper, rather than Sheehan's earlier papers on pituitary necrosis, led to the syndrome of post-partum pituitary necrosis becoming known as Sheehan's syndrome.[3]

Sheehan was the president of the section of endocrinology at the October 1960 meeting of the Royal Society of Medicine and gave an address Atypical Hypopituitarism.[7] He retired from the chair of pathology in 1965. From 1965 to 1980 in a room set aside for him at the Liverpool School of Tropical Medicine he studied his case notes and thousands of histopathological specimens accumulated over many years.[4]

He was elected FRCP in 1947, FRCOG in 1949, and FRCPath in 1964. He went on a number of international lecture tours, always accompanied by his wife, who spoke several languages.[3] He was elected a foreign correspondent of the Académie Nationale de Médecine.[4]

In 1934 in Kensington, London, he married Eve Suzette Gertrude Potter (1905–1986). They had no children. Both of them were buried at Allerton Cemetery.

Selected publications

Articles

Books
  • with H. C. Moore: Renal cortical necrosis. Oxford: Blackwell Scientific. 1952.
  • with J. B. Lynch: The pathology of toxaemia of pregnancy. Edinburgh: Churchill Livingstone. 1973.[8][9]
  • with J. C. Davis: Post-partum hypopituitarism. Springfield, Illinois: C. C. Thomas. 1982.

References
  1. Sheehan's syndrome at Who Named It?
  2. "Sheehan's syndrome". Mayo Clinic.
  3. "Harold Leeming Sheehan". Lives of the Fellows, Royal College of Physicians, Munk's Roll, Volume VIII.
  4. "Obituary. H. L. Sheehan, TD, DSc, MD, FRCP, FRCOG, FRCPath". Br Med J. 297 (6661): 1465. 3 December 1988. doi:10.1136/bmj.297.6661.1465.
  5. "Obituary. J. Shaw Dunn, M.D., MSc". Br Med J. 2 (4356): 27–29. 1 July 1944. doi:10.1136/bmj.2.4356.27. PMC 2285736.
  6. "Victor Kirwan Summers". Lives of the Fellows, Royal College of Physicians, Munk's Roll, Volume VI.
  7. Sheehan, H. L. (January 1961). "Atypical Hypopituitarism, President's Address, Section of Endocrinology, Meeting October 26 1960". Proceedings of the Royal Society of Medicine. 54 (1): 43–48. doi:10.1177/003591576105400111. PMC 1869477. PMID 19994084.
  8. Lindheimer, Marahall D. (January 1975). "Review of Pathology of toxaemia of pregnancy by H. L. Sheehan and J. B. Lynch". Obstetrics & Gynecology. 45 (1): 119.
  9. Woodcock, A. S. (16 June 1973). "Review of Pathology of Toxaemia of Pregnancy by H. L. Sheehan and J. B. Lynch". Br Med J. 2 (5867): 671. doi:10.1136/bmj.2.5867.671. PMC 1589686.
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